IZUMO1
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Official Full Name
izumo sperm-egg fusion 1 -
Overview
The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma;membrane binding and fusion (Inoue et al., 2005 (PubMed 15759005)). -
Synonyms
IZUMO1;izumo sperm-egg fusion 1;izumo sperm-egg fusion protein 1;IZUMO;MGC34799;OBF;oocyte binding/fusion factor;sperm-specific protein Izumo;FLJ61440
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Human Cell
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- His&Myc
Involved Pathway
IZUMO1 involved in several pathways and played different roles in them. We selected most pathways IZUMO1 participated on our site, such as Fertilization,Reproduction,Sperm:Oocyte Membrane Binding, which may be useful for your reference. Also, other proteins which involved in the same pathway with IZUMO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fertilization | CATSPER1,ZP3,IZUMO4,ADAM20,ZP2,CATSPERG1,ADAM30,OVGP1,ADAM2,HVCN1 |
| Reproduction | HVCN1,ADAM2,OVGP1,CATSPERG1,CATSPERB,CATSPER3,CATSPERG2,IZUMO4,ZP3,CATSPER2 |
| Sperm:Oocyte Membrane Binding | IZUMO4 |
Protein Function
IZUMO1 has several biochemical functions, for example, protein homodimerization activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IZUMO1 itself. We selected most functions IZUMO1 had, and list some proteins which have the same functions with IZUMO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | TCF3,CASQ2,FBXO4,ACAT1,TGFB1,CRYBA1,CEACAM5,ATF3,RQCD1,LGALS6 |
| receptor binding | GRP,RIPK2,CXCL10,PICK1,NMU,SMARCD1,TAC1,CDH5,HACL1,PECR |
Interacting Protein
IZUMO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IZUMO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IZUMO1.
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References
- Mizukami, M; Tokunaga, H; et al. Highly efficient production of VHH antibody fragments in Brevibacillus choshinensis expression system. PROTEIN EXPRESSION AND PURIFICATION 105:23-32(2015).
- Inoue, N; Hamada, D; et al. Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion. DEVELOPMENT 140:3221-3229(2013).
