IVD
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Official Full Name
isovaleryl-CoA dehydrogenase -
Overview
Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
IVD;isovaleryl-CoA dehydrogenase;isovaleryl CoA dehydrogenase , isovaleryl Coenzyme A dehydrogenase;isovaleryl-CoA dehydrogenase, mitochondrial;ACAD2;mitochondrial;FLJ12715;FLJ34849;Isovaleryl CoA dehydrogenase;Isovaleryl CoA dehydrogenase, mitochondrial;Isovaleryl Coenzyme A dehydrogenase;IVD_HUMAN
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Chicken
- Mouse
- Mammalian Cells
- E.coli
- Insect Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IVD-11536Z | Recombinant Zebrafish IVD | Mammalian Cells | Zebrafish | His |
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| IVD-1943H | Recombinant Human Isovaleryl Coenzyme A dehydrogenase, His-tagged | E.coli | Human | His |
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| IVD-29875TH | Recombinant Human IVD, His-tagged | E.coli | Human | His | 394 amino acids |
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| IVD-29876TH | Recombinant Human IVD, His-tagged | E.coli | Human | His | Full L. 30-423 a.a. |
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| IVD-3129R | Recombinant Rat IVD Protein | Mammalian Cells | Rat | His |
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| IVD-4390C | Recombinant Chicken IVD | Mammalian Cells | Chicken | His |
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| Ivd-8172M | Recombinant Mouse Ivd protein, His & T7-tagged | E.coli | Mouse | His&T7 | Met1~Phe235 |
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| IVD-8642H | Recombinant Human IVD protein, His-tagged | Insect Cells | Human | His | His30-His423 |
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| IVD-001HCL | Recombinant Human IVD cell lysate | Insect Cells | Human | Non | 30-423 a.a. |
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| IVD-2644H | Recombinant Human IVD Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| IVD-2785R | Recombinant Rat IVD Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| IVD-2785R-B | Recombinant Rat IVD Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Ivd-3623M | Recombinant Mouse Ivd Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| IVD-4942H | Recombinant Human IVD Protein, GST-tagged | Wheat Germ | Human | GST |
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| IVD-5848HF | Recombinant Full Length Human IVD Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 423 amino acids |
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| IVD-5996H | Recombinant Human IVD Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| IVD-876M | Recombinant Mouse IVD Protein (His31-Arg424), His-tagged | Insect Cells | Mouse | His | His31-Arg424 |
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Involved Pathway
IVD involved in several pathways and played different roles in them. We selected most pathways IVD participated on our site, such as Branched-chain amino acid catabolism,Metabolic pathways,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with IVD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Valine, leucine and isoleucine degradation | ACAA1,ACAD8,HIBCH,ALDH2.1,ALDH9A1A.1,AOX2P,HADHAA,IL4I1,HADH,ALDH2.2 |
| Metabolic pathways | ADI1,ACACB,PFKMA,NADKA,URAH,HSD17B4,PPAP2B,ACO2,DAO,ATP6V1C2 |
| Metabolism | ALOX5AP,SLC25A32,APOEB,INSIG2,SUMF2,CIAPIN1,ACOT11A,PFKLB,GPAT2,AK7 |
| Metabolism of amino acids and derivatives | DCT,PCBD1,CKBA,DIO2,NAALAD2,ACMSD,CKMT2A,BCKDK,CKB,NQO1 |
| Branched-chain amino acid catabolism | PPM1K,HIBADHA,BCKDK,DLD,ALDH9A1A.2,DBT,HIBADH |
Protein Function
IVD has several biochemical functions, for example, electron carrier activity,fatty-acyl-CoA binding,flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IVD itself. We selected most functions IVD had, and list some proteins which have the same functions with IVD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| flavin adenine dinucleotide binding | DMGDH,DUS1L,ACADVL,TXNRD2,GCDH,GFER,ETFDH,DUS4L,NDOR1,ACAD11 |
| oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | ETFA,GCDH,ACAD11,GCDHB,ACOX1,ACADL,ACOX3,ACAD9,GCDHA,ACADSB |
| electron carrier activity | PHGDH,AOC2,FDX1L,ETFA,COX5A,ACADS,SDHC,PRKRA,NDUFS1,ACOXL |
| fatty-acyl-CoA binding | ACOXL,ALDH6A1,SOAT1,DBIL5,GCDH,ACBD5A,ACBD5,ACADL,ACADM,ACBD5B |
Interacting Protein
IVD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IVD here. Most of them are supplied by our site. Hope this information will be useful for your research of IVD.
ssuA;SIRT4
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References
- Koerner, JD; Markova, DZ; et al. Differential Gene Expression in Anterior and Posterior Annulus Fibrosus. SPINE 39:1917-1923(2014).
- Vashist, SK; Schneider, EM; et al. Rapid sandwich ELISA-based in vitro diagnostic procedure for the highly-sensitive detection of human fetuin A. BIOSENSORS & BIOELECTRONICS 67:73-78(2015).
