ITPKB
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Official Full Name
inositol-trisphosphate 3-kinase B -
Overview
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. -
Synonyms
ITPKB;inositol-trisphosphate 3-kinase B;inositol 1,4,5 trisphosphate 3 kinase B;IP3 3KB;IP3KB;1D myo inositol trisphosphate 3 kinase B;Inositol 1 4 5 trisphosphate 3 kinase B;Inositol trisphosphate 3 kinase B;IP3 3 kinase;IP3 3 kinase B;IP3K;IP3K B;PIG 37;PIG37;Proliferation inducing protein 37;IP3 3-kinase B;insP 3-kinase B;OTTHUMP00000035705;proliferation-inducing protein 37;inositol 1,4,5-trisphosphate 3-kinase B;IP3K-B;IP3-3KB
Recombinant Proteins
- Rat
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- His
- Non
- Avi
- Fc
- GST
- SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ITPKB-3124R | Recombinant Rat ITPKB Protein | Mammalian Cells | Rat | His |
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| ITPKB-883HCL | Recombinant Human ITPKB cell lysate | Human | Non |
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| ITPKB-2780R | Recombinant Rat ITPKB Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| ITPKB-2780R-B | Recombinant Rat ITPKB Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ITPKB-4949H | Recombinant Human ITPKB Protein, GST-tagged | Wheat Germ | Human | GST |
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| ITPKB-5840HF | Recombinant Full Length Human ITPKB Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 644 amino acids |
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| ITPKB-591H | Recombinant Human ITPKB Protein (442-946 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 442-946 aa |
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Involved Pathway
ITPKB involved in several pathways and played different roles in them. We selected most pathways ITPKB participated on our site, such as 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian),Calcium signaling pathway,D-myo-inositol (1,3,4)-trisphosphate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | MED18,COX16,MED23,AKR1C6,CPNE1,SCO1,SGMS2,SLC2A3,SLC25A10,CYP2U1 |
| Calcium signaling pathway | ADCY2B,HRH2,HTR2B,PPP3CB,TACR3,P2RX4B,CAMK2D2,ADORA2B,GRIN1B,SLC8A1B |
| Synthesis of IP3 and IP4 in the cytosol | PLCD3,ITPKA |
| 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) | ITPKA,ITPK1 |
| Phosphatidylinositol signaling system | PI4KB,INPP4A,PLCD4,PPIP5K2,PIP5K1AA,PIP4K2C,MTMR7,CALM2,MTMR6,PIP4K2A |
| Metabolic pathways | C1GALT1,ENPP1,TKTL2,NAT1,KDSR,A4GALT,ADH2-1,GNPDA1,LPIN2,URAH |
| D-myo-inositol (1,3,4)-trisphosphate biosynthesis | ITPKA |
| Inositol phosphate metabolism | MINPP1,INPP1,MTMR1B,MTMR7A,PLCD1B,IPMK,PIP4K2C,INPP5K,NUDT10,PIKFYVE |
Protein Function
ITPKB has several biochemical functions, for example, ATP binding,calmodulin binding,inositol-1,4,5-trisphosphate 3-kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPKB itself. We selected most functions ITPKB had, and list some proteins which have the same functions with ITPKB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol-1,4,5-trisphosphate 3-kinase activity | IPMKB,IP6K2,IPMK,ITPKA,ITPKC,IP6K1,IP6K3 |
| protein binding | CHMP5,LTBR,TCF25,NR1I2,EIF4E2,NPHP3,TMSB10,FUT11,VIM,BMI1 |
| calmodulin binding | NRGN,CNN3A,CAMK2D1,MAPKAPK5,PLA2G6,RIT1,MARCKS,VAMP2,GRIN1,SLC14A2 |
| ATP binding | GLULC,TRMU,CHD7,PIK3CD,STK10,CSNK1A1L,DDX53,CSNK1G2A,NARS2,SMYHC2 |
Interacting Protein
ITPKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPKB here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPKB.
GOLGA2;PSME3;PDE4A;PDE4D;PDE4D;ADNP2;PIBF1;ESF1
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