ITPKB

  • Official Full Name

    inositol-trisphosphate 3-kinase B

  • Overview

    The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.

  • Synonyms

    ITPKB;inositol-trisphosphate 3-kinase B;inositol 1,4,5 trisphosphate 3 kinase B;IP3 3KB;IP3KB;1D myo inositol trisphosphate 3 kinase B;Inositol 1 4 5 trisphosphate 3 kinase B;Inositol trisphosphate 3 kinase B;IP3 3 kinase;IP3 3 kinase B;IP3K;IP3K B;PIG 37;PIG37;Proliferation inducing protein 37;IP3 3-kinase B;insP 3-kinase B;OTTHUMP00000035705;proliferation-inducing protein 37;inositol 1,4,5-trisphosphate 3-kinase B;IP3K-B;IP3-3KB

Recombinant Proteins

  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • E.coli
  • His
  • Non
  • His&Fc&Avi
  • GST
  • His&SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
ITPKB-3124R Recombinant Rat ITPKB Protein Mammalian Cells Rat His
ITPKB-883HCL Recombinant Human ITPKB cell lysate Human Non
ITPKB-2780R Recombinant Rat ITPKB Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ITPKB-2780R-B Recombinant Rat ITPKB Protein Pre-coupled Magnetic Beads HEK293 Rat
ITPKB-4949H Recombinant Human ITPKB Protein, GST-tagged Wheat Germ Human GST
ITPKB-5840HF Recombinant Full Length Human ITPKB Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 644 amino acids
ITPKB-591H Recombinant Human ITPKB Protein (442-946 aa), His-SUMO-tagged E.coli Human His&SUMO 442-946 aa

    Involved Pathway

    ITPKB involved in several pathways and played different roles in them. We selected most pathways ITPKB participated on our site, such as 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian),Calcium signaling pathway,D-myo-inositol (1,3,4)-trisphosphate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism MTP,CYP27A1,BRSK2,MED8,APOEA,SPRB,MED15,CYP2D6,PRKRA,AK8
    Inositol phosphate metabolism IPMKB,MTMR7B,INPPL1A,PLCD3A,INPP4B,INPPL1,PTEN,PIP5KL1,MINPP1A,PIP5K1BB
    Calcium signaling pathway CCKAR,TACR1A,DRD7,SPHK1,P2RX4,PDGFRA,EDNRB2,TACR3L,PTGER3,GRPR
    Metabolic pathways UGT1A9,CYP2J2,COQ7,POLR2EB,FUT7,POLR3D,PFAS,IL4I1,LDHBB,PPOX
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis ITPKA
    Phosphatidylinositol signaling system INPP5L,ITPK1A,MTMR1A,PIK3R3B,CALM3B,PIP4K2B,PIK3R1,DGKD,PIK3CG,MTMR8
    Synthesis of IP3 and IP4 in the cytosol ITPKA,PLCD3
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) ITPKA,ITPK1

    Protein Function

    ITPKB has several biochemical functions, for example, ATP binding,calmodulin binding,inositol-1,4,5-trisphosphate 3-kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPKB itself. We selected most functions ITPKB had, and list some proteins which have the same functions with ITPKB. You can find most of the proteins on our site.

    Function Related Protein
    inositol-1,4,5-trisphosphate 3-kinase activity IP6K1,IPMK,ITPKC,IP6K3,IP6K2,ITPKA,IPMKB
    calmodulin binding RYR2,RASGRF2,NRGNA,CASK,SNTB2,PPP3R1,MYH9,DAPK1,RIT1,CAMKK1
    ATP binding GSS,BMPR2,ACTR3,OASL2,PAK3,UBE2D2,CAMK1GA,TSSK3,GUCY2C,P2RX3
    protein binding AIMP2,SERPINB8,STAT3,SLX4,MME,NPLOC4,ZMYND10,RPL27A,NUDCD3,CEP350

    Interacting Protein

    ITPKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPKB here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPKB.

    GOLGA2;PSME3;PDE4A;PDE4D;PDE4D;ADNP2;PIBF1;ESF1

    Resources

    References

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All ITPKB Products

    Required fields are marked with *

    My Review for All ITPKB Products

    Required fields are marked with *