ITGB8

  • Official Full Name

    integrin, beta 8

  • Overview

    This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

  • Synonyms

    ITGB8;integrin, beta 8;integrin beta-8;ITGB 8;OTTHUMP00000025212

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rabbit
  • Oryctolagus cuniculus (Rabbit)
  • E.coli
  • Mammalian Cells
  • HEK293
  • Yeast
  • Wheat Germ
  • GST
  • His
  • Non
  • His&Fc&Avi
  • His&Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ITGB8-183H Recombinant Human ITGB8, GST-tagged E.coli Human GST 76-439aa
ITGB8-2317R Recombinant Rhesus monkey ITGB8 Protein, His-tagged Mammalian Cells Rhesus macaque His
ITGB8-881HCL Recombinant Human ITGB8 cell lysate Human Non
ITGB8-2138R Recombinant Rhesus Macaque ITGB8 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
ITGB8-2138R-B Recombinant Rhesus Macaque ITGB8 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
ITGB8-2220R Recombinant Rabbit ITGB8 Protein, His-tagged Yeast Rabbit His
ITGB8-2297R Recombinant Rabbit ITGB8 Protein (146-384 aa), His-Myc-tagged E.coli Rabbit His&Myc 146-384 aa
ITGB8-255H Recombinant Human ITGB8 Protein, His-tagged E.coli Human His Cys471~Thr629
ITGB8-4964H Recombinant Human ITGB8 Protein, GST-tagged Wheat Germ Human GST
RFL24947HF Recombinant Full Length Human Integrin Beta-8(Itgb8) Protein, His-Tagged E.coli Human His Full L. Full Length of Mature Protein (43-769)
RFL30290OF Recombinant Full Length Rabbit Integrin Beta-8(Itgb8) Protein, His-Tagged E.coli Oryctolagus cuniculus (Rabbit) His Full L. Full Length of Mature Protein (43-768)

    Involved Pathway

    ITGB8 involved in several pathways and played different roles in them. We selected most pathways ITGB8 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) SGCG,ACTG1,ITGA5,CACNG4,EMD,LMNA,CACNB4,ITGB6,ITGA7,TCF7L2
    Hypertrophic cardiomyopathy (HCM) CACNG3,IL6,ITGB3,CACNG4,DAG1,TPM1,ITGA1,LMNA,DMD,TPM2
    Focal adhesion MAPK8A,PAK2A,MET,PIK3R3,MYLK2,ACTG1,PAK2,PTK6,CDC42L,BADB
    PIK-Akt signaling pathway COL27A1,FGFR1,GSK3B,FGFR3,GYS1,TCL1B1,RPS6KB2,INS1,BCL2,LAMB3
    Dilated cardiomyopathy TPM3,TNF,ITGA5,TGFB1,CACNG2,CACNB4,ITGA7,ACTG1,ADRB1,MYH7
    Regulation of Actin Cytoskeleton ABI2,CHRM2A,FGF1,FGF6A,ITGB4,FN1A,RAC2,APC2,FGF8,ACTB
    ECM-receptor interaction SV2A,COL6A2,Itga10&Itgb1,DAG1,COL1A1A,CD44,Reln,SDC1,COL27A1,SV2B
    Cell adhesion molecules (CAMs) NCAM1A,ITGA9,MPZL1L,NRXN1A,ITGA6,BF2,CLDN2,ITGA8,HLA-E,VCAN

    Protein Function

    ITGB8 has several biochemical functions, for example, extracellular matrix protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB8 itself. We selected most functions ITGB8 had, and list some proteins which have the same functions with ITGB8. You can find most of the proteins on our site.

    Function Related Protein
    receptor activity TNFRSF9,CLEC4M,TLR1,CUL5,SMAGP,RAMP3,THRAP3,PVRL1A,NR2C1,NLGN3B
    extracellular matrix protein binding MEPE,ITGAV

    Interacting Protein

    ITGB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB8.

    ITGAV

    Resources

    Research Area

    Integrins
    Basolateral Molecules

    References

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