ISL1

  • Official Full Name

    ISL LIM homeobox 1

  • Overview

    This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]

  • Synonyms

    ISL1;ISL LIM homeobox 1;Isl-1;ISLET1;insulin gene enhancer protein ISL-1;islet-1;ISL1 transcription factor, LIM/homeodomain

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • Non
  • His&T7
  • His
  • Avi&Fc&His
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
ISL1-129H Recombinant Human ISL1 E.coli Human Non 1-100 a.a.
ISL1-149H Recombinant Human ISL1 Protein, T7/His/TEV-11R-tagged E.coli Human His&T7
ISL1-28841TH Recombinant Human ISL1 E.coli Human Non 100 amino acids
ISL1-3102R Recombinant Rat ISL1 Protein Mammalian Cells Rat His
ISL1-6965C Recombinant Chicken ISL1 Mammalian Cells Chicken His
ISL1-8599Z Recombinant Zebrafish ISL1 Mammalian Cells Zebrafish His
ISL1-5149HCL Recombinant Human ISL1 293 Cell Lysate HEK293 Human Non
ISL1-130H Recombinant Human ISL1 protein, His-T7-tagged E.coli Human His&T7 Met1~Gln191
ISL1-2758R Recombinant Rat ISL1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ISL1-2758R-B Recombinant Rat ISL1 Protein Pre-coupled Magnetic Beads HEK293 Rat
ISL1-3120H Recombinant Human ISL1 Protein (Met1-Ala349), N-His tagged E.coli Human His Met1-Ala349
ISL1-5015H Recombinant Human ISL1 Protein, GST-tagged Wheat Germ Human GST
ISL1-5764HF Recombinant Full Length Human ISL1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 346 amino acids

    Involved Pathway

    ISL1 involved in several pathways and played different roles in them. We selected most pathways ISL1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ISL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells FGFR3,FZD9,PIK3R5,WNT3A,WNT8B,PCGF2,PCGF3,NODAL,IL6ST,PCGF5

    Protein Function

    ISL1 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ISL1 itself. We selected most functions ISL1 had, and list some proteins which have the same functions with ISL1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding UPF3B,VRK1,PPP1R12A,RPLP2,LDLRAD1,TSSK4,LCA5,TXNL4B,SCNN1B,CDC42BPG
    zinc ion binding AMFR,TAF15,RARGA,TAB2,ADAM15,BTR30,ADH7,TRIM55A,ZNF257,ZCCHC7
    enhancer sequence-specific DNA binding ATF2,KLF7B,XBP1,FOXN4,SOX9,GATA5,KLF6A,LDB1,YY1,TFAP2B
    RNA polymerase II core promoter proximal region sequence-specific DNA binding HOXC11,POU4F2,PITX2,ATOH1,ZNF664,NKX3-2,ZFP536,T,ZNF502,NDN
    ligand-dependent nuclear receptor binding NCOR2,NCOA3,SLC30A9,MED1,TADA3,NCOR1,PPARGC1A,SRA1,NCOA1,C1D
    chromatin binding CENPA,SREBF1,ARID3A,FOS,RAD51,SP110,ATXN7,HMGA1,POU2F1,ING2
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding FOXC2,MYBL2,MEOX2,FOXI1,SOX12,ELK3,HOXC13,ONECUT1,SMAD1,IRF4
    RNA polymerase II activating transcription factor binding HIPK2,NHLH2,EOMES,MAD2L2,CREB1,SETD3,CTNNB1,TBX3,ATF2,SMAD3
    RNA polymerase II transcription coactivator activity CREBBP,PRRX1,TRIM28,NCOA1,TFAP2B,RERE,POU1F1,MED12L,SOX4,PSIP1

    Interacting Protein

    ISL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ISL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ISL1.

    ZNF511;CDK6;KDM1A;PLCG2;CDKN2B;CRK;SMAD3;RELA

    Resources

    Research Area

    Cardiac Stem Cell Markers
    Pancreatic Endoderm Cell Markers
    Motor Neuronal Markers
    Endodermal Lineage Markers

    References

    • Liu, J; Li, WQ; et al. Islet-1 Overexpression in Human Mesenchymal Stem Cells Promotes Vascularization Through Monocyte Chemoattractant Protein-3. STEM CELLS 32:1843-1854(2014).
    • Agaimy, A; Lell, M; et al. 'Neuroendocrine' middle ear adenomas: consistent expression of the transcription factor ISL1 further supports their neuroendocrine derivation. HISTOPATHOLOGY 66:182-191(2015).

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