IRS2

  • Official Full Name

    insulin receptor substrate 2

  • Overview

    This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin,;insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine;kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase;upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

  • Synonyms

    IRS2;insulin receptor substrate 2;IRS-2
Cat.# Product name Source (Host) Species Tag Protein Length Price
IRS2-1051H Recombinant Human IRS2 protein, His & T7-tagged E.coli Human His&T7 Ser985~Ala1255
IRS2-8314M Recombinant Mouse IRS2 Protein Mammalian Cells Mouse His
IRS2-3213H Recombinant Human IRS2 Protein (Ser985-Ala1255), N-His tagged E.coli Human His Ser985-Ala1255
IRS2-4611M Recombinant Mouse IRS2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
IRS2-4611M-B Recombinant Mouse IRS2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
IRS2-5029H Recombinant Human IRS2 Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    IRS2 involved in several pathways and played different roles in them. We selected most pathways IRS2 participated on our site, such as cGMP-PKG signaling pathway,FoxO signaling pathway,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of lipolysis in adipocytes PIK3R1,NPR1,PRKG2,PIK3CG,PTGS2,PLIN1,PIK3R3,INS2,AKT2,TSHR
    Insulin signaling pathway PIK3R2,PPP1R3A,EIF4E1B,FBP2,CALM,PRKAR2AB,SOCS2,MAPK8A,BADB,INPP5K
    Adipocytokine signaling pathway ACSL4A,PRKAG3,CAMKK1A,ACSL3B,ADIPOQ,AKT1,RXRGA,RELA,ACSL4B,MTOR
    Non-alcoholic fatty liver disease (NAFLD) NDUFS5,NDUFA3,PIK3R3,COX7B2,MAPK10,COX8C,PIK3R2,COX7A1,NDUFV2,RXRA
    Type II diabetes mellitus PRKCD,PKM2,HK2,INS2,IKBKB,INSR,MTOR,PIK3CA,IRS4,PDX1
    FoxO signaling pathway TGFB2,PRKAB1,SKP2,AKT2L,Fasl,EGFRA,MAPK12B,FOXO3B,TGFB3,FBXO25
    AMPK signaling pathway G6PC3,FASN,RHEB,PPP2R5C,AKT2,AKT3,CAB39,INSR,RAB8A,CAB39L
    cGMP-PKG signaling pathway MYLK3,PRKCE,PDE2A,PRKG1,PLN,RGS2,GNA11,NFATC2,GNA12,MAPK1
    Insulin resistance RPS6KB1,NR1H2,PPP1CAB,SREBF1,PPARAB,IKBKB,SLC2A4,PIK3CA,GYS2,PIK3CD

    Protein Function

    IRS2 has several biochemical functions, for example, 14-3-3 protein binding,insulin receptor binding,phosphatidylinositol 3-kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS2 itself. We selected most functions IRS2 had, and list some proteins which have the same functions with IRS2. You can find most of the proteins on our site.

    Function Related Protein
    14-3-3 protein binding PRKCE,SRPK2,PRKCZ,TSC2,RPTOR,YWHAQ,ARRB2,KIF13B,HDAC7,HDAC7A
    protein binding ADSS,ANTXR2,CSN3,MRPS27,CETN3,CCNT1,FYN,SLC22A17,CYHR1,SPAG8
    phosphatidylinositol 3-kinase binding INSRR,HCST,CALM2,FYN,TYRO3,CALM3,IRS4,JAK2,IGF1RA,CALM1
    protein kinase binding AP2A2,KIF13B,XBP1,ELP2,CCNL1A,HDAC7,BCL2L14,CCND2,AP1B1,EEF1A2
    protein domain specific binding RARA,TRP63,CALM,CNTROB,PPP3R1,YWHAH,TH,IGBP1,ZFP521,TFDP2
    insulin receptor binding DOK5,IRS1,SNX1,PDPK1,PHIP,FRS3,IGF1,INS,SNX2,SNX4
    protein phosphatase binding EGFR,VCP,KAT2A,ANAPC4,PPME1,ERBB2,ITGA1,TRP53,PPP6R3,CDH2

    Interacting Protein

    IRS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS2.

    Ncl;Znf592;Lonp1;TP53BP2;Insr;Phip;Sirt1;SIRT1;Lyn

    Resources

    Gene Families

    What Is Tumor Necrosis Factor (TNF)/TNF Superfamily

    Research Area

    phospho-Serine/phospho-Threonine Binding Proteins
    Endocrine Regulation of Lipid Metabolism

    References

    • Hancer, NJ; Qiu, W; et al. Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:12467-12484(2014).
    • Zerzaihi, O; Chriett, S; et al. Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 92:61-67(2014).

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