IRGM
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Official Full Name
immunity-related GTPase family, M -
Overview
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohns disease and tuberculosis. -
Synonyms
IRGM;immunity-related GTPase family, M;immunity related GTPase family, M1 , IRGM1;immunity-related GTPase family M protein;IFI1;LRG 47;LRG47;LRG-47-like protein;interferon-inducible protein 1;immunity-related GTPase family, M1;LPS-stimulated RAW
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IRGM-3098R | Recombinant Rat IRGM Protein | Mammalian Cells | Rat | His |
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| IRGM-394H | Recombinant Human immunity-related GTPase family, M, His-tagged | E.coli | Human | His | 23-181 a.a. |
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| IRGM-2754R | Recombinant Rat IRGM Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| IRGM-2754R-B | Recombinant Rat IRGM Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| IRGM-3118H | Recombinant Human IRGM protein, GST-tagged | E.coli | Human | GST | 1-181aa |
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| IRGM-5030H | Recombinant Human IRGM Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
IRGM involved in several pathways and played different roles in them. We selected most pathways IRGM participated on our site, such as Toxoplasmosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRGM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Toxoplasmosis | HLA-DRB5,PDPK1,TGFB3,HSPA1A,IL12B,PIK3CB,RELA,HSPA1L,LAMB4,TYK2 |
Protein Function
IRGM has several biochemical functions, for example, GTP binding,hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRGM itself. We selected most functions IRGM had, and list some proteins which have the same functions with IRGM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RHOGB,DNM1L,ERAL1,ARFRP1,HBS1L,NPR1,RALBA,GCH1,DIRAS2,TUBB2 |
| hydrolase activity | PM20D2,DHX33,KLK1B8,KLK1B5,ATAD1A,EXO5,PNPLA8,ASAH1A,CTSJ,YTHDC2 |
Interacting Protein
IRGM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRGM here. Most of them are supplied by our site. Hope this information will be useful for your research of IRGM.
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References
- Ciccacci, C; Perricone, C; et al. A Multilocus Genetic Study in a Cohort of Italian SLE Patients Confirms the Association with STAT4 Gene and Describes a New Association with HCP5 Gene. PLOS ONE 9:-(2014).
- Lee, KM; Lee, JM; et al. Crohn's disease in Korea: past, present, and future. KOREAN JOURNAL OF INTERNAL MEDICINE 29:558-570(2014).
- Murdoch, TB; Xu, W; et al. Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease. INFLAMMATORY BOWEL DISEASES 18:1743-1748(2012).
