IRF6
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Official Full Name
interferon regulatory factor 6 -
Overview
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011] -
Synonyms
IRF6;interferon regulatory factor 6;LPS;PIT;PPS;VWS;OFC6;PPS1;VWS1
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Rhesus macaque
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
- GST
- Flag
Involved Pathway
IRF6 involved in several pathways and played different roles in them. We selected most pathways IRF6 participated on our site, such as Apoptosis,Cytokine Signaling in Immune system,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine Signaling in Immune system | IL17RD,HLA-DQB2,NUP50,TRIM10,IFIT10,CNKSR1,IFI27,WDR83,IFIT8,NOD1 |
| Apoptosis | PPP3R1B,BADB,PIK3CD,CFLARA,HRK,ENDOG,BNIP3LB,AKT1,NMT1,HIST1H1E |
| Interferon gamma signaling | HLA-DQB2,TRIM14,TRIM17,TRIM31,GBP2,IRF4,FCGR1B,IFI30,TRIM48,TRIM8 |
| Immune System | DDX41,MICA,CTSH,NCKAP1,CD300C,UBE2F,KIF22,RAPGEF3,DYNC1I2,TXNIPB |
| Interferon alpha/beta signaling | GBP2,IFI35,MX2,USP18,SAMHD1,IRF9,XAF1,IFITM3,IFI6,IFIT2 |
| Interferon Signaling | IFI27,GBP4,HERC5,IFIT10,IFI6,IRF9,IFIT2,TRIM62,IFIT3,TRIM5 |
Protein Function
IRF6 has several biochemical functions, for example, DNA binding,protein binding,regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF6 itself. We selected most functions IRF6 had, and list some proteins which have the same functions with IRF6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| regulatory region DNA binding | IRF4A,IRF8,HMGA2,IRF5,NFKB1,IRF2A,IRF1B,IRF1A,IRF3 |
| protein binding | ZW10,PPP1R9A,VDAC2,ESYT2,SPRYD7,TAOK3,ALPP,TTC6,FGF1,TNFSF13B |
| DNA binding | ZNF791,ZBED2,ARID5B,ZNF124,IRX4A,NRL,ZNF446,CEBPG,FOXP3A,TERF1 |
| transcription factor activity, sequence-specific DNA binding | LBX1,POU2F1B,HOXB7,ZSCAN4C,FOXI1,ZNF461,ZNF189,SOX11B,RARGA,CDX1B |
Interacting Protein
IRF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF6.
IRF8;IRF5;BNC2
Resources
Research Area
Apoptosis Transcription Factors and RegulatorsEpithelial Stem Cell Transcription Factors
Ectodermal Lineage Markers
Related Services
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References
- Koelsch, KA; Webb, R; et al. Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse. JOURNAL OF AUTOIMMUNITY 41:168-174(2013).
