IREB2
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Official Full Name
iron responsive element binding protein 2 -
Synonyms
IREB2;iron responsive element binding protein 2;iron-responsive element-binding protein 2;IRE-BP 2;iron regulatory protein 2;Irp2;D9Ertd85e;DKFZp564D1164
Recombinant Proteins
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Human
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- His&T7
- Myc&DDK
- GST
- Flag
Involved Pathway
IREB2 involved in several pathways and played different roles in them. We selected most pathways IREB2 participated on our site, such as Iron metabolism in placenta,Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with IREB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Validated targets of C-MYC transcriptional activation | PDCD10,MYCT1,SERPINI1,PRDX3,MINA,DDX18,NDUFAF2,LIN28B,CDCA7,MTDH |
| Iron metabolism in placenta | HAMP,TFR2 |
Protein Function
IREB2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,RNA binding,iron-responsive element binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IREB2 itself. We selected most functions IREB2 had, and list some proteins which have the same functions with IREB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TPM4,FSTL1,GGA2,ATP1A2,HSPB6,RPL39L,UXT,FKBP8,PRR16,MAP3K7IP3 |
| metal ion binding | FTR82,DGKD,MGAT4B,ZNF643,PDCD2,CHD4A,TRAF4B,BSN,KLF13,QTRT1 |
| iron-responsive element binding | FECH,ACO1 |
| translation repressor activity | EIF4EBP2,PAIP2,PATL2,EIF4EBP3,EIF4EBP1,CIRBP,SAMD4A,TRIM71,SAMD4 |
| 4 iron, 4 sulfur cluster binding | TYW1,NUBP1,ISCU,NDUFS1,POLE,NDUFV1,ACO1,ISCUB,NDUFS8A,ACO2 |
| RNA binding | IFIT11,RPLP1,OASL1,EXOSC5,PCBP2,PUS10,AHCYL1,AGO3B,EWSR1,NABP1 |
Interacting Protein
IREB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IREB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IREB2.
purL;USP53;Cdc20;Hdac6
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References
- Garrick, MD; Kuo, HC; et al. Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion. BIOCHEMICAL JOURNAL 398:539-546(2006).
- Popovic, Z; Templeton, DA; et al. A Northwestern blotting approach for studying iron regulatory element-binding proteins. MOLECULAR AND CELLULAR BIOCHEMISTRY 268:67-74(2005).
