IPO4
-
Official Full Name
importin 4 -
Overview
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. -
Synonyms
IPO4;importin 4;Imp4;importin-4;imp4b;ranBP4;importin-4b;ran-binding protein 4
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IPO4-144H | Recombinant Human IPO4, GST-tagged | E.coli | Human | GST | C-term-354aa | |
| IPO4-8263M | Recombinant Mouse IPO4 Protein | Mammalian Cells | Mouse | His |
|
|
| Ipo4-1689M | Recombinant Mouse Ipo4 Protein, His-tagged | E.coli | Mouse | His | Met1-Arg189 |
|
| IPO4-2444H | Recombinant Human IPO4 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| IPO4-293H | Recombinant Human IPO4 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
|
|
| Ipo4-3565M | Recombinant Mouse Ipo4 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
|
|
| IPO4-4580M | Recombinant Mouse IPO4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| IPO4-4580M-B | Recombinant Mouse IPO4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
IPO4 involved in several pathways and played different roles in them. We selected most pathways IPO4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IPO4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
IPO4 has several biochemical functions, for example, Ran GTPase binding,nuclear localization sequence binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IPO4 itself. We selected most functions IPO4 had, and list some proteins which have the same functions with IPO4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SPACA3,DBNDD2,MAPK14,PI4KA,MECOM,STX6,STAG1,TRIM35,PPIA,MRPL20 |
| nuclear localization sequence binding | BRAP,NUP214,KPNA1,KPNA7,IPO13,KPNA6,TNPO1,KPNB1,KPNA4,KPNA2 |
| protein transporter activity | XPO6,KPNA7,AP2A1,COG2,AP1G1,IPO5,VPS26BL,VPS26A,TIMM9,IPO7 |
| Ran GTPase binding | RANBP1,BIRC5,CSE1L,RANGRF,RANBP3,XPO5,IPO11,XPO4,NXT1,IPO13 |
Interacting Protein
IPO4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IPO4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IPO4.
MYC;HIST1H3D;q76353_9hiv1;7242199;SGK1;PTP4A3;CIAO1;BAP1;BRF2;NEK6;ASF1B;GSTK1;PHLDA3;p27958-pro_0000037576;VAV2;ezrA;MED19
Resources
Related Services
Related Products
References
- Loginsky, VE; Vygovska, YI; et al. Immunophenotypic characterization of blood lymphoid cells in chronic lymphocytic leukemia complicated by immune cytopenias. EXPERIMENTAL ONCOLOGY 18:37-42(1996).
