INSIG1
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Official Full Name
insulin induced gene 1 -
Overview
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. -
Synonyms
INSIG1;insulin induced gene 1;insulin-induced gene 1 protein;CL 6;INSIG 1 membrane protein;MGC1405;CL6;INSI1_HUMAN;INSIG 1;INSIG-1;INSIG1 membrane protein;Insulin induced gene 1 protein;INSIG-1 membrane protein;CL-6
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Cynomolgus
- Mouse
- Mus musculus
- Bovine
- zebrafish
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Cricetulus griseus
- Xenopus laevis
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&GST
- His&Fc&Avi
Involved Pathway
INSIG1 involved in several pathways and played different roles in them. We selected most pathways INSIG1 participated on our site, such as Metabolism,Metabolism of lipids and lipoproteins,Regulation of cholesterol biosynthesis by SREBP (SREBF), which may be useful for your reference. Also, other proteins which involved in the same pathway with INSIG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of lipids and lipoproteins | CYP2V1,ACOT11B,EBP,SCP2B,SLC44A5B,FABP12,SGMS2,CPNE7,DHCR24,FA2H |
| Metabolism | AKR1C6,COX18,COX6C,DUT,PEMT,PDP2,CEPT1,NUDT3B,LMF1,KHK |
| SREBP signalling | RBP4,DBI,RNF139,SEC23B,INSIG2 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | DHCR7,NFYAL,YY2,NFYBB,NFYBA,INSIG2,MTF1,PMVK,SREBF2 |
Protein Function
INSIG1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSIG1 itself. We selected most functions INSIG1 had, and list some proteins which have the same functions with INSIG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CRELD2,PEX11B,NDUFAF4,POU3F3,MAPK8IP3,GRID2IP,LNX2B,DTX3,PPP1R11,CRNKL1 |
Interacting Protein
INSIG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSIG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of INSIG1.
SEC27;copa_schpo;CYP2C1;CYP2C2;COP1
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References
- Wang, WX; Wilfred, BR; et al. Individual microRNAs (miRNAs) display distinct mRNA targeting "rules". RNA BIOLOGY 7:373-380(2010).
