INPPL1
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Official Full Name
inositol polyphosphate phosphatase-like 1 -
Overview
SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and tw -
Synonyms
INPPL1;inositol polyphosphate phosphatase-like 1;phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2;51C protein;SHIP2;SHIP-2;INPPL-1;protein 51C;SH2 domain-containing inositol 5-phosphatase 2;SH2 domain-containing inositol-5-phosphatase 2
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- His
- Avi
- Fc
- GST
Involved Pathway
INPPL1 involved in several pathways and played different roles in them. We selected most pathways INPPL1 participated on our site, such as Inositol phosphate metabolism,Phosphatidylinositol signaling system,B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPPL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | IGHM,DUSP4,DOK3,NFATC2,CRK,PTPN18,DOK1B,PDK2,ITPR2,DAPP1 |
| Inositol phosphate metabolism | IPMK,PIK3C2A,PI4K2A,PIP5K2,PIKFYVE,PLCB2,PIP5K1AA,MTMR1A,NUDT3A,INPP5KA |
| Phosphatidylinositol signaling system | MTMR3,PLCD3A,PIP4K2A,PLCD1B,INPP5E,MTMR7,CALM1B,PIP4K2C,CALM2B,MTMR1A |
| Fc gamma R-mediated phagocytosis | MAPK1,cgr2b,PIK3R3,PIK3R2,PLA2G4D,CFL2,PPAP2B,LIMK2,PLA2G4A,ASAP3 |
| Insulin signaling pathway | G6PC2,PPP1CB,RPTOR,INSR,PIK3CG,ACACA,AKT2L,HRAS,MKNK2,PRKACAB |
Protein Function
INPPL1 has several biochemical functions, for example, SH2 domain binding,SH3 domain binding,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INPPL1 itself. We selected most functions INPPL1 had, and list some proteins which have the same functions with INPPL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol-3,4,5-trisphosphate binding | RACGAP1,ZFYVE16,COMMD1,RAG2,ARAP3,ASAP1,ARHGAP9,MYO1G,AKT1,BTK |
| actin binding | RUSC1,ACTN3B,UPF3B,EPB41L2,PFN1,MYH7B,PLECA,MYO1H,NF2,MYH11A |
| SH2 domain binding | PAG1,SIT1,LAT2,SKAP1,KHDRBS2,SHCBP1,LILRB1,GNB2L1,CRK,NUP62 |
| protein binding | DIP2A,CIR1,PRCP,CLIC1,PDPK1,PEF1,RAPGEF6,TRAPPC2L,AKAP17A,DDB2 |
| inositol-polyphosphate 5-phosphatase activity | INPP5J,INPP5E,INPP5D,INPP5K,INPP5A |
| hydrolase activity | NUDT17,PNPLA1,HINT3,POR,DOM3Z,EHD2,AGBL1,FAAH2A,PSMB11,C6AST3 |
| SH3 domain binding | DENND1A,GPX1,SH3BGR,EPS15,CRB3,GRB2,CD2AP,SH3BGRL2,INPP5D,ELMO3 |
Interacting Protein
INPPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of INPPL1.
PTPN1;Sorbs3;Itsn1;Shc1;LRRK1
Resources
Research Area
Phosphatases and RegulatorsPhosphatases Localized to Focal Adhesions
T Follicular Helper (Tfh) Cells
Related Services
Related Products
References
- Iida, A; Okamoto, N; et al. Exome sequencing identifies a novel INPPL1 mutation in opsismodysplasia. JOURNAL OF HUMAN GENETICS 58:391-394(2013).
- Below, JE; Earl, DL; et al. Whole-Genome Analysis Reveals that Mutations in Inositol Polyphosphate Phosphatase-like 1 Cause Opsismodysplasia. AMERICAN JOURNAL OF HUMAN GENETICS 92:137-143(2013).
