INPP1
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Official Full Name
inositol polyphosphate-1-phosphatase -
Overview
This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. -
Synonyms
INPP1;inositol polyphosphate-1-phosphatase;inositol polyphosphate 1-phosphatase;EC 3.1.3.57;Inositol polyphosphate 1 phosphatase;IPP;IPPase
Recombinant Proteins
- Human
- Mouse
- HEK293
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| INPP1-117H | Recombinant Human INPP1, His-tagged | HEK293 | Human | His | 1-399 a.a. |
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| INPP1-8223M | Recombinant Mouse INPP1 Protein | Mammalian Cells | Mouse | His |
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| INPP1-5200HCL | Recombinant Human INPP1 293 Cell Lysate | HEK293 | Human | Non |
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| INPP1-2728H | Recombinant Human INPP1 Protein (Met1-Thr399), C-His tagged | Mammalian Cells | Human | His | Met1-Thr399 |
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| Inpp1-3543M | Recombinant Mouse Inpp1 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| INPP1-4554M | Recombinant Mouse INPP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| INPP1-4554M-B | Recombinant Mouse INPP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| INPP1-5112H | Recombinant Human INPP1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| INPP1-5894HF | Recombinant Full Length Human INPP1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 399 amino acids |
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Involved Pathway
INPP1 involved in several pathways and played different roles in them. We selected most pathways INPP1 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | NUDT3B,MTMR1,ITPK1A,ITPKC,MTMR4,ITPKB,INPP5KA,MTMR3,NUDT3A,ISYNA1 |
| Phosphatidylinositol signaling system | CALM3B,PLCB3,PLCD3A,CDS1,OCRL,PI4KAA,MTMR2,IP6K1,CALM2B,PIP5K2 |
| Metabolic pathways | FUT2,COQ7,PGLS,PCXB,AMPD3B,POLR2A,ACSM4,FBP1,GCDHB,GCSH |
Protein Function
INPP1 has several biochemical functions, for example, inositol-1,3,4-trisphosphate 1-phosphatase activity,inositol-1,4-bisphosphate 1-phosphatase activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP1 itself. We selected most functions INPP1 had, and list some proteins which have the same functions with INPP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol-1,3,4-trisphosphate 1-phosphatase activity | CTDSPL2A,SACM1LA,TENC1,CTDSPL2B,PXYLP1,SACM1LB,PTPRQ,SACM1L,NT5DC3,SGPP2 |
| magnesium ion binding | PRPS1B,DCTPP1,TREX2,ATP9A,PRPS1,NUAK2,COMT,NT5C1B,NUDT3,ATP10A |
Interacting Protein
INPP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP1.
LIG1;DYNLL1
Resources
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References
- Tarique, KF; Rehman, SAA; et al. Structure-based identification of inositol polyphosphate 1-phosphatase from Entamoeba histolytica. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70:3023-3033(2014).
- Tarique, KF; Rehman, SAA; et al. Structural elucidation of a dual-activity PAP phosphatase-1 from Entamoeba histolytica capable of hydrolysing both 3 '-phosphoadenosine 5 '-phosphate and inositol 1,4-bisphosphate. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70:2019-2031(2014).
