ING5
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Official Full Name
inhibitor of growth family, member 5 -
Overview
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. -
Synonyms
ING5;inhibitor of growth family, member 5;inhibitor of growth protein 5;FLJ23842;p28ING5;1700001C14Rik;1700027H23Rik;1810018M11Rik;ING 5;ING-5;Inhibitor of growth family member 5;p28 ING 5;p28 ING-5;p28 ING5
Recombinant Proteins
- Rhesus macaque
- Human
- Chicken
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ING5-2270R | Recombinant Rhesus monkey ING5 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| ING5-27620TH | Recombinant Human ING5, His-tagged | E.coli | Human | His | 2-240 a.a. |
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| ING5-2966C | Recombinant Chicken ING5 | Mammalian Cells | Chicken | His |
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| ING5-7383H | Recombinant Human ING5 protein, GST-tagged | E.coli | Human | GST | Glu36-Gln84 |
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| ING5-8211M | Recombinant Mouse ING5 Protein | Mammalian Cells | Mouse | His |
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| ING5-5205HCL | Recombinant Human ING5 293 Cell Lysate | HEK293 | Human | Non |
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| ING5-2091R | Recombinant Rhesus Macaque ING5 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ING5-2091R-B | Recombinant Rhesus Macaque ING5 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| ING5-4546M | Recombinant Mouse ING5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ING5-4546M-B | Recombinant Mouse ING5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ING5-5124H | Recombinant Human ING5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ING5-5879HF | Recombinant Full Length Human ING5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 240 amino acids |
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Involved Pathway
ING5 involved in several pathways and played different roles in them. We selected most pathways ING5 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with ING5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | SMYD2,ZZZ3,USP22,BRPF1,PHF2,ING3,SMARCB1B,COPRS,PADI6,PRMT5 |
| HATs acetylate histones | KAT6B,JADE1,MBIP,RUVBL2,SAP130,TADA2B,MORF4L1,RBB4L,ING3,ELP2 |
| Chromatin organization | BRD8,PADI1,SMARCB1A,GATAD2A,SMARCD3,ACTL6B,KIAA1267,MSL1,DMAP1,PADI3 |
Protein Function
ING5 has several biochemical functions, for example, chromatin binding,methylated histone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ING5 itself. We selected most functions ING5 had, and list some proteins which have the same functions with ING5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | LIMS1,Ar,MYT1,NR2E3,ESR1,NR5A2,TRIM12A,NR1D4B,ENPEP,Npepo |
| methylated histone binding | ING3,CDYL2,JHDM1D,CBX4,FAM156A,UHRF1,TP53BP1,RBBP5,WDR92,CBX5 |
| chromatin binding | RAD51,GATA6,MTA3,BRD3,KLF14,NR5A2,NCOA2,MECP2,KDM1A,POU2F1 |
| protein binding | DAPP1,PDE4A,DAK,LIG3,BMP4,PFN1,CEP72,CORO2B,H3F3A,AUP1 |
Interacting Protein
ING5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ING5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ING5.
NAV2;CCDC67;80125;HGS;ARFIP2;KRTAP10-7;ICA1
Resources
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References
- Zhang, F; Baumer, N; et al. The Inhibitor of Growth Protein 5 (ING5) Depends on INCA1 as a Co-Factor for Its Antiproliferative Effects. PLOS ONE 6:-(2011).
