ING1
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Official Full Name
inhibitor of growth family, member 1 -
Overview
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a;nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53;signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple;alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
ING1;inhibitor of growth family, member 1;inhibitor of growth protein 1;growth inhibitor ING1;growth inhibitory protein ING1;inhibitor of growth 1;p24ING1c;p33;p33ING1;p33ING1b;p47;p47ING1a;tumor suppressor ING1
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- Sf9 Cells
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- Non
- Avi&Fc&His
- DDK&Myc
- GST
Involved Pathway
ING1 involved in several pathways and played different roles in them. We selected most pathways ING1 participated on our site, such as Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with ING1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Senescence and Autophagy | IL24,FKBP8,ING2,RSL1D1,MAP1LC3C,MAP1LC3B,GABARAP,SLC39A2,SLC39A3,IFI16 |
Protein Function
ING1 has several biochemical functions, for example, methylated histone binding,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ING1 itself. We selected most functions ING1 had, and list some proteins which have the same functions with ING1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| methylated histone binding | PHF13,CBX5,JHDM1D,RAG2,SPIN1,ZMYND11,CBX7,PHF2,CDYL2,PHF8 |
| zinc ion binding | MKRN3,PHF23,CHORDC1,ZDHHC2,MT1X,ZMIZ1A,CPA4,ZFAND1,MMP16,MUL1B |
| protein binding | KLF2,CNOT10,RPS28,ASNS,VSIG4,KIAA0947,LMO1,CYLD,TK1,TRIM31 |
Interacting Protein
ING1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ING1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ING1.
NQO1;CTRL;h3_peptide_2-18;UBC;YWHAQ;YWHAB;SFN;YWHAG;YWHAE;YWHAZ;YWHAH;HDAC1;MRGBP
Resources
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References
- Ahmed, IAM; Kelly, SB; et al. The predictive value of p53 and p33(ING1b) in patients with Dukes'C colorectal cancer. COLORECTAL DISEASE 10:344-351(2008).
- Suzuki, K; Boland, D; et al. Domain Recognition of the ING1 Tumor Suppressor by a Panel of Monoclonal Antibodies. HYBRIDOMA 30:239-245(2011).
