IMPDH1
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Official Full Name
IMP (inosine 5-monophosphate) dehydrogenase 1 -
Overview
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] -
Synonyms
IMPDH1;IMP (inosine 5-monophosphate) dehydrogenase 1;IMPD;RP10;IMPD1;LCA11;sWSS2608;inosine-5-monophosphate dehydrogenase 1;IMPD 1;IMPDH 1;IMPDH-I;IMP dehydrogenase 1;IMP (inosine monophosphate) dehydrogenase 1
Recombinant Proteins
- Human
- Mouse
- Sf21 Cells
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
IMPDH1 involved in several pathways and played different roles in them. We selected most pathways IMPDH1 participated on our site, such as Purine metabolism,Drug metabolism - other enzymes,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Drug metabolism - other enzymes | PNAT3,UGT1A6B,UGT1A6A,DPYD,Ces2c,UCK2B,NAT,CES1,UGT1A6,UGT2A1 |
| Metabolic pathways | POLR3D,NDUFS3,CERS5,ATP5D,Nat3,ARG2,AZIN2,ALG2,PTDSS1,PKM2 |
| Purine metabolism | ENTPD6,PAPSS2,PDE1A,GUK1,NME2,HPRT1,ADAL,PDE6H,POLR3GL,POLR2H |
Protein Function
IMPDH1 has several biochemical functions, for example, DNA binding,IMP dehydrogenase activity,RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPDH1 itself. We selected most functions IMPDH1 had, and list some proteins which have the same functions with IMPDH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ATP13A3,CYP2C54,FDPS,PVALB1,TYRP1B,RNASEH2A,XGB,CYCS,ALOX5B.2,ZFP335 |
| nucleic acid binding | JRKL,PABPC1A,INSM1B,REXO4,ZNF865,BAT1,HNRNPA3,WBP4,CLIP1,ZBTB10 |
| DNA binding | ZBTB16,NFIXB,ZFP653,POLR3K,VENT,ZNF582,ZBTB39,ZNF445,RARAB,ZNF383 |
| IMP dehydrogenase activity | IMPDH1A,IMPDH2,IMPDH1B |
| RNA binding | CAPRIN1,ZNF74,SURF6,NSUN6,RDBP,EXOSC9,RNASEH2A,PES,EIF2S2,OASL1 |
Interacting Protein
IMPDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPDH1.
GMNN;q7cfv5_yerpe;HTRA1;MYO1C;SEC16A;XRCC3;Junb;Lgals3bp;EMC2;Rpl35;MMGT1
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