ILKAP
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Official Full Name
integrin-linked kinase-associated serine/threonine phosphatase -
Overview
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. -
Synonyms
ILKAP;integrin-linked kinase-associated serine/threonine phosphatase;integrin linked kinase associated serine/threonine phosphatase 2C;integrin-linked kinase-associated serine/threonine phosphatase 2C;DKFZP434J2031;FLJ10181;protein phosphatase 2c, d
Recombinant Proteins
- Human
- Rat
- Mouse
- HEK293
- E.coli
- Mammalian Cell
- Human Cell
- E. coli
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- N-His and C-His
- Myc&DDK
- His&Fc&Avi
- His&SUMO
- GST
Involved Pathway
ILKAP involved in several pathways and played different roles in them. We selected most pathways ILKAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ILKAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ILKAP has several biochemical functions, for example, metal ion binding,protein binding,protein serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ILKAP itself. We selected most functions ILKAP had, and list some proteins which have the same functions with ILKAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine phosphatase activity | DUSP23B,PPP3CB,CDC14AB,PPP4C,PPM1N,PPM1LA,MTMR4,PPP1R3C,PPM1F,CDC14C |
| protein binding | KARS,IRF9,CYSLTR1,CREBZF,DHX8,EIF5A,PURA,BAP1,PRKG1,TLR1 |
| metal ion binding | HDAC9,NUBP2,RORCB,ZFP551,DNLZ,AIFM3,TRIM55B,NANOS1,PRKD2,GALNTL2 |
Interacting Protein
ILKAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ILKAP here. Most of them are supplied by our site. Hope this information will be useful for your research of ILKAP.
ILK;pi3p;15-deoxy-delta(12,14;LTN1;STAT5A;C21orf59;PDK1;CHST15;Wdr48;FBXO18;CERK
Resources
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References
- Arroyo-Berdugo, Y; Alonso, S; et al. Involvement of ANXA5 and ILKAP in Susceptibility to Malignant Melanoma. PLOS ONE 9:-(2014).
- Zhou, W; Cao, H; et al. Characterization of Nuclear Localization Signal in the N Terminus of Integrin-linked Kinase-associated Phosphatase (ILKAP) and Its Essential Role in the Down-regulation of RSK2 Protein Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 288:6259-6271(2013).
