ILF3
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Official Full Name
interleukin enhancer binding factor 3, 90kDa -
Overview
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
ILF3;interleukin enhancer binding factor 3, 90kDa;interleukin enhancer binding factor 3, 90kD;interleukin enhancer-binding factor 3;DRBP76;M phase phosphoprotein 4;MPHOSPH4;MPP4;NF90;NFAR 1;M-phase phosphoprotein 4;translational control protein
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- Flag
- His
- T7
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
ILF3 involved in several pathways and played different roles in them. We selected most pathways ILF3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ILF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ILF3 has several biochemical functions, for example, DNA binding,RNA binding,double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ILF3 itself. We selected most functions ILF3 had, and list some proteins which have the same functions with ILF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NKX3.3,ZFP292,ZNF668,ERCC2,GCM1,MYC,CHD1,ZNF823,TERF1,HOPX |
| protein binding | PIK3CG,ELF3,VAMP1,PEX26,RABGGTB,AP2A1,FCRL4,AGTR1A,PAK6,DNAJB1 |
| double-stranded RNA binding | TFRC,OASL2,DHX30,SLC3A2,ZNF346,TUBA1B,APTX,TLR8,OAS1,TLR7 |
| RNA binding | EIF3B,RBM4B,SNRPF,RANBP2,RBM46,RBFOX1L,XPO1,RPL6,DUSP11,METTL14 |
| poly(A) RNA binding | NVL,EIF3A,EIF2S2,PWP2,MRPL28,SNRPN,ZFP106,SRP54,LLPH,RBM19 |
Interacting Protein
ILF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ILF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ILF3.
YBX1;ILF2;VP35;PRMT1;VCAM1
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