IL1RAP
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Official Full Name
interleukin 1 receptor accessory protein -
Overview
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. -
Synonyms
IL1RAP;interleukin 1 receptor accessory protein;IL1R3;C3orf13;IL-1RAcP;IL-1R3;interleukin-1 receptor 3;interleukin-1 receptor accessory protein beta;OTTHUMP00000209487;OTTHUMP00000209488;OTTHUMP00000209489;OTTHUMP00000209490;OTTHUMP00000209491;OTTHUMP00000209492;IL-1 receptor accessory protein;OTTHUMP00000209493;FLJ37788;interleukin-1 receptor accessory protein;OTTHUMP00000209485;OTTHUMP00000209486;IL-1R-3
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- Mouse
- Rat
- Macaca mulatta
- E.coli
- Human Cells
- HEK293
- Sf21 Cells
- Mammalian Cells
- His
- Fc&His
- Fc
- Non
- Avi&Fc
- Avi&His
- Flag
- His&T7
- DDK&Myc
- Avi&Fc&His
- His&Myc
Involved Pathway
IL1RAP involved in several pathways and played different roles in them. We selected most pathways IL1RAP participated on our site, such as Cytokine-cytokine receptor interaction,Apoptosis,Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1RAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | IRF4,CTNNB1,IRF2A,IRF1B,CASP3A,IL1B2,CASP6L1,PRKAR1B,NFKBIAB,PPP3CC |
| Cytokine-cytokine receptor interaction | CXCL8B.3,PDGFB,FASLG,KITLGA,CCL4L2,TNFRSF12A,IL1R2,IL23R,CXCL14,GH2 |
| Inflammatory mediator regulation of TRP channels | PRKCQ,CYP4A12A,GNAQ,GNAS,ITPR1,NTRK1,TRPV1,MAP2K3,CYP2C54,CAMK2G |
Protein Function
IL1RAP has several biochemical functions, for example, interleukin-1 receptor activity,interleukin-1 receptor binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1RAP itself. We selected most functions IL1RAP had, and list some proteins which have the same functions with IL1RAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-1 receptor binding | IL36G,IL36B,Il1f6,IL36A,IL1A,TLR9,IL1RN,TRIP6,IL1B,IRAK4 |
| interleukin-1 receptor activity | IL1RAPL2,IL1RAPL1A,IL1R1,IL1RL1,IL1RL2,IL18R1,IL1R2 |
| signal transducer activity | ACKR3B,HCAR1-1,PTK2B,TAS2R110,TAS1R2.1,GNG13A,CC2D1A,PTGER1C,OR115-6,OLFR474 |
Interacting Protein
IL1RAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1RAP here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1RAP.
IL1B;IL1R2;IL1R1;SMAD2;TICAM2;PRPF40A;MC4R;PRKCI;KPNA1;CCNI
Resources
Research Area
NeuroinflammationInflammatory Mediators
Multiple Sclerosis and Myelin Related Molecules
Rheumatoid arthritis Therapeutic Targets
NOD-like Receptors and the Inflammasome
Th17 Cells
Th2 Cells
IL-1 Family Receptors
CAR-T Cell Therapy Targets
Related Services
Related Products
References
- Askmyr, M; Agerstam, H; et al. Selective killing of candidate AML stem cells by antibody targeting of IL1RAP. BLOOD 121:3709-3713(2013).
- Jaras, M; Johnels, P; et al. Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:16280-16285(2010).
- Jaras, M; Johnels, P; et al. ISOLATION AND KILLING OF CANDIDATE CML STEM CELLS BY ANTIBODY TARGETING OF IL1RAP. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 95:242-242(2010).
