IKZF2
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Official Full Name
IKAROS family zinc finger 2 (Helios) -
Overview
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. -
Synonyms
IKZF2;IKAROS family zinc finger 2 (Helios);zinc finger protein, subfamily 1A, 2 (Helios) , ZNFN1A2;zinc finger protein Helios;Helios;ikaros family zinc finger protein 2;zinc finger DNA binding protein Helios;zinc finger protein, subfamily 1A, 2 (Helios);ANF1A2;ZNF1A2;ZNFN1A2;MGC34330
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- His
- Non
- Avi&Fc&His
- His&Myc
- GST
Involved Pathway
IKZF2 involved in several pathways and played different roles in them. We selected most pathways IKZF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IKZF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
IKZF2 has several biochemical functions, for example, metal ion binding,molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKZF2 itself. We selected most functions IKZF2 had, and list some proteins which have the same functions with IKZF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZDHHC16A,HMOX1,ZFP93,TRIM35-23,S100A10B,ZNF292B,SUZ12A,ING5B,CDK15,ZNF329 |
| transcription regulatory region DNA binding | HINFP,BRD7,NKX2-5,ARRB1,KCNA3,PAX8,MLL1,ZFP161,HNF1A,NKX2 |
| protein heterodimerization activity | SOX17,YWHAH,ADRB1,SCUBE1,MYOD1,USF2,DLG4B,ZFP423,BCL2,PRSS28 |
| molecular_function | TMEM229A,TMCC1B,TAS2R110,GM14434,CTDSPL,TMEM51A,SPRYD7B,SDSL,KIAA0247,GM13304 |
| protein homodimerization activity | KIAA0947,PRPS2,FAM109B,CER1,NR0B1,PRKG2,CHMP4B,APOE,C16orf89,SYT6 |
| protein binding | NUP37,FST,RPS7,GDPD5,FAN1,SMCO4,S100A8,CHMP2A,HDAC7,TRIM63 |
| transcription factor activity, sequence-specific DNA binding | MZF1,PBX1A,ZNF726,L3MBTL1,PHF5A,E2F8,TFAP2B,GRHL3,ZNF26,PTF1A |
Interacting Protein
IKZF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKZF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IKZF2.
Hoxa1;AQP1;CTBP2;LONRF1;CTBP2;MYC;HDAC1
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