IKZF1
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Official Full Name
IKAROS family zinc finger 1 -
Overview
Ikaros functions in the specification and the maturation of the T lymphocyte. It also interacts with a critical control element in the terminal deoxynucleotidyltransferase promoter as well as with the promoters for other genes expressed during early stages of B and T cell development. -
Synonyms
IKZF1;IKAROS family zinc finger 1;DNA-binding protein Ikaros;ikaros family zinc finger protein 1;lymphoid transcription factor LyF-1;zinc finger protein subfamily 1A, 1;zinc finger protein, subfamily 1A, 1 (Ikaros);LyF-1;hlk-1;Ikaros;Zfpn1a1;Znfn1a1;mKIAA4227;5832432G11Rik;KIAA4227
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- HEK293
- E.coli
- Mammalian Cells
- DDK
- Myc
- His
- T7
- Non
- Avi
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IKZF1-125H | Recombinant Human IKZF1 protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| IKZF1-182H | Recombinant Human IKZF1 protein, T7/His-tagged | E.coli | Human | His&T7 |
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| IKZF1-6645C | Recombinant Chicken IKZF1 | Mammalian Cells | Chicken | His |
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| IKZF1-8622Z | Recombinant Zebrafish IKZF1 | Mammalian Cells | Zebrafish | His |
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| IKZF1-850HCL | Recombinant Human IKZF1 cell lysate | Human | Non |
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| IKZF1-2552H | Recombinant Human IKZF1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| Ikzf1-3498M | Recombinant Mouse Ikzf1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| IKZF1-3889H | Recombinant Human IKZF1 Protein (Met1-Ser519), C-MYC/DDK tagged | Mammalian Cells | Human | DDK&Myc | Met1-Ser519 |
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| IKZF1-4416H | Recombinant Human IKZF1 protein, His-Avi-tagged | E.coli | Human | Avi&His | 1-477aa |
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| IKZF1-9822HFL | Recombinant Full Length Human IKZF1 protein, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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Involved Pathway
IKZF1 involved in several pathways and played different roles in them. We selected most pathways IKZF1 participated on our site, such as Calcineurin-regulated NFAT-dependent transcription in lymphocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKZF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | EGR3,EGR2,IRF4,EGR4,CTLA4,BATF3,JUNB,POU2F1,EGR1,CDK4 |
Protein Function
IKZF1 has several biochemical functions, for example, DNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKZF1 itself. We selected most functions IKZF1 had, and list some proteins which have the same functions with IKZF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PDCD1,FZD8,RP2,SYNJ2,MAPKBP1,GPR85,GTF2E2,SPINLW1,TARBP2,MAST2 |
| protein heterodimerization activity | ADORA1,SYCP3,ARNT2,PPP2R4,NKX2-5,H2AFY,HIST1H2AC,TAS1R2,SOX14,YWHAE |
| metal ion binding | MAP3K13,GEN1,LONRF1L,ATP2A1L,ZBTB16A,ZNF74,PRICKLE2B,BGLAP2,FTR50,RBM26 |
| transcription regulatory region DNA binding | TNF,GABPB1,RFX6,CREB3L2,GLI1,ZFP382,TFE3,SFPQ,SOX2,REST |
| transcription factor activity, sequence-specific DNA binding | NME2,KLF12,RORA,ZIC5,BACH2,RORCA,DMRT2B,TCEAL1,FOXA1,CITED2 |
| sequence-specific DNA binding | GRHL2,CAMTA2,NR4A1,HOXB13,FOXA,HOXD10,PHOX2BB,HOXC11A,DMRT2B,BHLHE22 |
| DNA binding | ZFP276,SETDB1A,PLSCR1,BTBD11A,NR1D1,SP4,ARID1AA,NHEJ1,TSNAX,NEUROD4 |
Interacting Protein
IKZF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKZF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IKZF1.
DCX;RAD51D;CTBP2;RWDD2B;FAM214B
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