IKZF1

  • Official Full Name

    IKAROS family zinc finger 1

  • Overview

    Ikaros functions in the specification and the maturation of the T lymphocyte. It also interacts with a critical control element in the terminal deoxynucleotidyltransferase promoter as well as with the promoters for other genes expressed during early stages of B and T cell development.

  • Synonyms

    IKZF1;IKAROS family zinc finger 1;DNA-binding protein Ikaros;ikaros family zinc finger protein 1;lymphoid transcription factor LyF-1;zinc finger protein subfamily 1A, 1;zinc finger protein, subfamily 1A, 1 (Ikaros);LyF-1;hlk-1;Ikaros;Zfpn1a1;Znfn1a1;mKIAA4227;5832432G11Rik;KIAA4227

Recombinant Proteins

  • Human
  • Chicken
  • Zebrafish
  • Mouse
  • HEK293
  • E.coli
  • Mammalian Cell
  • HEK293T
  • Mammalian cells
  • Mamanlian cells
  • Myc&DDK
  • His&T7
  • His
  • Non
  • His&Avi
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
IKZF1-125H Recombinant Human IKZF1 protein, MYC/DDK-tagged HEK293 Human Myc&DDK
IKZF1-182H Recombinant Human IKZF1 protein, T7/His-tagged E.coli Human His&T7
IKZF1-6645C Recombinant Chicken IKZF1 Mammalian Cell Chicken His
IKZF1-8622Z Recombinant Zebrafish IKZF1 Mammalian Cell Zebrafish His
IKZF1-850HCL Recombinant Human IKZF1 cell lysate Human Non
IKZF1-2552H Recombinant Human IKZF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Ikzf1-3498M Recombinant Mouse Ikzf1 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
IKZF1-3889H Recombinant Human IKZF1 Protein (Met1-Ser519), C-MYC/DDK tagged Mammalian cells Human Myc&DDK Met1-Ser519
IKZF1-4416H Recombinant Human IKZF1 protein, His-Avi-tagged E.coli Human His&Avi 1-477aa
IKZF1-9822HFL Recombinant Full Length Human IKZF1 protein, Flag-tagged Mamanlian cells Human Flag Full L.

    Involved Pathway

    IKZF1 involved in several pathways and played different roles in them. We selected most pathways IKZF1 participated on our site, such as Calcineurin-regulated NFAT-dependent transcription in lymphocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKZF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes JUNB,EGR2,BATF3,IRF4,EGR4,EGR3,DGKA,CTLA4,CSF2,EGR1

    Protein Function

    IKZF1 has several biochemical functions, for example, DNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKZF1 itself. We selected most functions IKZF1 had, and list some proteins which have the same functions with IKZF1. You can find most of the proteins on our site.

    Function Related Protein
    sequence-specific DNA binding NR6A1A,AHR2,SIX4A,MAFK,SOX2,TCF7L1A,GZF1,PBX3B,POU4F2,MKX
    DNA binding MUS81,CXXC1B,TBX22,ZMYM4,JUN,RYBP,RAD51D,FOXE1,TFB1M,TCF15
    metal ion binding ADCY1,ZNF684,MORC2B,OVCH2,PRICKLE1A,ZNF230,ZFP458,ZFP92,FEZF2,ITGA2B
    transcription regulatory region DNA binding GLI1,AIRE,TP53,ATF3,CBX4,ATMIN,CREB3L2,ATF4,ARRB1,THRA
    protein binding PXN,PPP1R9A,MSI2,TSC2,CT45A3,SLC6A18,ATG5,PNKD,STX7,PTGIS
    protein heterodimerization activity ZFP423,TLX1,SAE1,GCLC,BCL2L2,PRMT5,PDGFA,SUPT5H,GTF2A1,MYF5
    transcription factor activity, sequence-specific DNA binding FOXD4,SALL1,PROX1,FOXF2,HOXB5B,ZNF812,RBPJA,STAT1B,FBXW7,BATF3

    Interacting Protein

    IKZF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKZF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IKZF1.

    DCX;RAD51D;CTBP2;RWDD2B;FAM214B

    Resources

    Research Area

    Plasmacytoid Dendritic Cells
    B Cell Transcription Factors
    Dendritic Cell Development

    References

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