IGSF6
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Official Full Name
immunoglobulin superfamily, member 6 -
Overview
Using a cDNA subtraction technique, a novel member of the immunoglobulin superfamily was isolated from human dendritic cells (DCs). This cDNA, named DORA, for Down-Regulated by Activation encodes a protein belonging to the CD8 family of receptors containing a single V type loop domain with an associated J chain region, a transmembrane region containing an atypical tyrosine residue and a cytoplasmic domain containing three putative tyrosine phosphorylation sites. The human DORA gene has been mapped to chromosome 16. Expression is observed in DCs, purified ex vivo or generated in vitro from either monocytes or CD34+ progenitors, and down-regulated following activation by PMA and Ionomycin or by CD40L engagement. -
Synonyms
immunoglobulin superfamily member 6;down-regulated by activation (immunoglobulin superfamily);IGSF6;Protein DORA;DORA;OTTHUMP00000115880;immunoglobulin superfamily, member 6
Recombinant Proteins
- Rat
- Chicken
- Human
- Mouse
- Mus musculus
- Mammalian Cells
- HEK293
- E.coli
- His
- Myc&DDK
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
IGSF6 involved in several pathways and played different roles in them. We selected most pathways IGSF6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IGSF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
IGSF6 has several biochemical functions, for example, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IGSF6 itself. We selected most functions IGSF6 had, and list some proteins which have the same functions with IGSF6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | EBP,NRXN3,SELE,KLRD1,OR4D6,TLR7,LEPR,TLR5,CR2,MARCO |
Interacting Protein
IGSF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGSF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGSF6.
lipA
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References
- Mei, H; Campbell, JM; et al. Regulation of Endothelial Cell Barrier Function by Antibody-driven Affinity Modulation of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1). JOURNAL OF BIOLOGICAL CHEMISTRY 289:20836-20844(2014).
- Zhang, M; Luo, WT; et al. Overexpression of JAM-A in Non-Small Cell Lung Cancer Correlates with Tumor Progression. PLOS ONE 8:-(2013).
