IGFALS
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Official Full Name
insulin-like growth factor binding protein, acid labile subunit -
Overview
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
IGFALS;insulin-like growth factor binding protein, acid labile subunit;insulin-like growth factor-binding protein complex acid labile subunit;ALS;insulin-like growth factor binding protein complex acid labile chain
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
IGFALS involved in several pathways and played different roles in them. We selected most pathways IGFALS participated on our site, such as Metabolism of proteins,Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFALS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | MAN1A2,ADAMTSL4,CPE,TIMM8A,ASNA1,TRAPPC6A,ARSE,EIF5A2,ADAMTSL3,DPH2 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | PAPPA2,IGFBP6,IGFBP5B,IGFBP1A,IGFBP4,IGFBP6B,IGFBP2,PAPPAB,IGFBP2A,PAPPA |
Protein Function
IGFALS has several biochemical functions, for example, insulin-like growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFALS itself. We selected most functions IGFALS had, and list some proteins which have the same functions with IGFALS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| insulin-like growth factor binding | HTRA3,IGFBP1B,IGF1R,HTRA4,IGFBP2B,WISP2,HTRA1A,CYR61,IGFBP7,IGF2R |
Interacting Protein
IGFALS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFALS here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFALS.
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