IGF2BP3

  • Official Full Name

    insulin-like growth factor 2 mRNA binding protein 3

  • Overview

    Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor. The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded prot

  • Synonyms

    IGF2BP3;insulin-like growth factor 2 mRNA binding protein 3;insulin-like growth factor 2 mRNA-binding protein 3;cancer/testis antigen 98;CT98;IGF II mRNA binding protein 3;IMP 3;hKOC;VICKZ family member 3;IGF2 mRNA-binding protein 3;IGF-II mRNA-binding protein 3;KH domain containing protein overexpressed in cancer;KH domain-containing protein overexpressed in cancer;IMP3;KOC1;IMP-3;VICKZ3;DKFZp686F1078;OTTHUMP00000158561;VICKZ3.

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • GST
  • His
  • His&T7
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
IGF2BP3-14103H Recombinant Human IGF2BP3 protein, GST-tagged E.coli Human GST 240-579 aa
IGF2BP3-3360H Recombinant Human IGF2BP3 protein, His-tagged E.coli Human His 240-579 aa
IGF2BP3-1503C Recombinant Chicken IGF2BP3 Mammalian Cell Chicken His
IGF2BP3-16H Recombinant Human IGF2BP3 protein, His/T7-tagged E.coli Human His&T7 2-343 a.a.
IGF2BP3-17H Recombinant Human IGF2BP3 protein, His-tagged E.coli Human His 2-579 a.a.
IGF2BP3-8068M Recombinant Mouse IGF2BP3 Protein Mammalian Cell Mouse His
IGF2BP3-9044Z Recombinant Zebrafish IGF2BP3 Mammalian Cell Zebrafish His
IGF2BP3-3437H Recombinant Human IGF2BP3 Protein (Asn2-Ile343), N-His tagged E.coli Human His Asn2-Ile343
IGF2BP3-4464M Recombinant Mouse IGF2BP3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
IGF2BP3-4464M-B Recombinant Mouse IGF2BP3 Protein Pre-coupled Magnetic Beads HEK293 Mouse
IGF2BP3-5147H Recombinant Human IGF2BP3 Protein, GST-tagged Wheat Germ Human GST 1-579 a.a.
IGF2BP3-533H Recombinant Human IGF2BP3 protein, His-tagged E.coli Human His 1-579aa
IGF2BP3-5855HF Recombinant Full Length Human IGF2BP3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 579 amino acids

    Involved Pathway

    IGF2BP3 involved in several pathways and played different roles in them. We selected most pathways IGF2BP3 participated on our site, such as Gene Expression,Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF2BP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression BRF2,GATAD2B,ADAR,THG1L,PLD6,ZNF100,DHX9,ZNF143B,CCNT2A,TRMT44
    Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA IGF2BP2,IGF2BP1

    Protein Function

    IGF2BP3 has several biochemical functions, for example, RNA binding,mRNA 3-UTR binding,mRNA 5-UTR binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF2BP3 itself. We selected most functions IGF2BP3 had, and list some proteins which have the same functions with IGF2BP3. You can find most of the proteins on our site.

    Function Related Protein
    nucleotide binding PPIP5K2,IGF1RB,PPARGC1A,Akap17b,DCLK1A,SBK1,BLM,ABCC8,CSTF2,HNRPLL
    mRNA 3-UTR binding CPEB4,CARHSP1,ELAVL2,CRYZ,RBMS3,ANGEL2,CPEB3,RBM4,SERBP1,TUT1
    translation regulator activity RPS9,AIRE,YBX2,IGF2BP1,RPS14,IGF2BP2
    RNA binding DZIP3,MARF1,PAPOLA,JAKMIP1,DCP2,ASCC1,SMN1,RPL15,THOC5,HNRPL
    poly(A) RNA binding BST2,RPS8,P4HB,TFB2M,NOA1,CLK3,SAMD4B,MANF,ZFP579,MRPS15
    mRNA 5-UTR binding IGF2BP2,LARP1,RPS14,MRPS11,IGF2BP1,DDX3X
    protein binding RNF115,TIMM50,MRPL40,DNAJC15,KIAA0247,GUCY1B3,KIAA1279,CCDC53,PAM,AIFM1

    Interacting Protein

    IGF2BP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF2BP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF2BP3.

    CNBP;Ybx1;POLR1E;PUF60;midostaurin;ssrna_ug

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