IGF2BP2
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Official Full Name
Insulin-like growth factor 2 mRNA binding protein 2 -
Overview
Insulin-like growth factors (IGFs) regulate the proliferation, differentation, apoptose, cell adhesion and metabolism in various tissues and cell types. The IGF-I, which is produced mainly in liver under the influence of Growth Hormone (GH), regulates as hormone the linear growth of the bones and the process of sexual maturity, while IGF-II is mainly a growth factor of foetal tissue. The biological actions of IGF over the IGF-Type-I receptor are modulated variably through the IGF binding proteins (IGFBP-1 to-6). IGFBP-2 is, after IGFBP-3, the second most frequent IGFBP in the human blood. IGFs, especially tumor typical pro-IGF-forms and hormones regulate the expression of IGFBP-2, GH effect is thereby inhibiting. At cellular level IGFBP-2 seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism. IGFBP-2 is an unglycosylated polypetide of 31.3 kDa, which forms binary IGF-complexes and shows no circadian rhythm in the circulation. The serum concentration of IGFBP-2 increases in fasting, after major surgery and after trauma, but the increasing of the concentration is most intensive in malignant diseases. The correlation of the IGFBP-2 level to the degree of progression is a striking feature in various tumor types as is the normalization of the IGFBP-serum levels after remission. During the GH-therapy, e.g. in short stature and in GH-abuse (doping) the IGFBP-2 level decreases. In Trisomy 18 IGFBP-2 in maternal serum is decreased and IGFBP-1 is increased; therefore the ratio IGFBP-2 /IGFBP-1 is a marker for this chromosome abnormality. Transgenic organisms are a good opportunity to investigate the function of genes or proteins. The mouse model is a well-suited system for investigation of the relevance of IGFBP-2 in physiological and pathological processes. Over expression of the IGFBP-2 gene in mice results in a weight reduction of 30% in spleen and moderately reduced weight in other organs. Effects of IGFBP-2 on the organism can be compensated through the modified expression of other IGF-Binding proteins. Especially in tumor biology the mouse system enables investigation of the systemic relevance of IGFBP-2. IGFBP-2 influences tumor cells as it induces catalase activity in adrenocortical cells. Furthermore IGFBP-2 interacts with tumor cells via its RGD-amino acid sequence and seems to stimulate cell invasion of glioma cells. -
Synonyms
RP23-50H13.1;C330012H03Rik;IMP-2;Imp2;Neilsen;IGF-II mRNA-binding protein 2;IGF2 mRNA-binding protein 2;VICKZ family member 2;insulin-like growth factor 2 mRNA-binding protein 2;insulin-like growth factor 2, binding protein 2
Recombinant Proteins
- Human
- Mouse
- Insect Cells
- Mammalian Cell
- Insect Cell
- HEK293
- E.coli
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- Mammalian cells
- His&GST
- His
- Non
- His&Fc&Avi
- His&T7
- Myc&DDK
- GST
- Flag
Involved Pathway
IGF2BP2 involved in several pathways and played different roles in them. We selected most pathways IGF2BP2 participated on our site, such as Gene Expression,Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF2BP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | IGF2BP3,IGF2BP1 |
| Gene Expression | ZNF689,MED7,MYBL1,TSEN34,ZNF333,GLS2B,LCMT2,ZKSCAN4,POLR3GLA,WARS2 |
Protein Function
IGF2BP2 has several biochemical functions, for example, mRNA 3-UTR binding,mRNA 5-UTR binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF2BP2 itself. We selected most functions IGF2BP2 had, and list some proteins which have the same functions with IGF2BP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mRNA 5-UTR binding | LARP1,IGF2BP1,DDX3X,IGF2BP3,RPS14,MRPS11 |
| nucleotide binding | RABL6,MYO15,RAC1B,UBE2D1B,LMTK3,PABPC1L2A,MAPKAPK2A,U2AF1,CELF4,RBM17 |
| protein binding | NINJ2,CBX5,RNF168,TNF,ASPH,SLC52A2,NAP1L1,DDIT3,VARS2,YY1AP1 |
| mRNA 3-UTR binding | IGF2BP3,RBMS3,CPEB3,FXR1,LARP1,YBX2,CIRBP,RNF40,CSDA,PUM1 |
| translation regulator activity | IGF2BP1,YBX2,AIRE,RPS9,RPS14,IGF2BP3 |
| poly(A) RNA binding | RBM6,AATF,NGDN,SMNDC1,RRP12,ZNF207,SND1,YTHDC1,HNRPDL,RPS17L |
Interacting Protein
IGF2BP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF2BP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF2BP2.
YBX1;MYC;HNRNPD;38mer;CNBP;PUF60;GSTK1;HNRNPD;pta;ssrna_ug
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References
- Laggai, S; Kessler, SM; et al. The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. JOURNAL OF LIPID RESEARCH 55:1087-1097(2014).
- Salem, SD; Saif-Ali, R; et al. IGF2BP2 Alternative Variants Associated with Glutamic Acid Decarboxylase Antibodies Negative Diabetes in Malaysian Subjects. PLOS ONE 7:-(2012).
