IFT122
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Official Full Name
intraflagellar transport 122 homolog (Chlamydomonas) -
Overview
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. -
Synonyms
IFT122;intraflagellar transport 122 homolog (Chlamydomonas);WD repeat domain 10 , WDR10;intraflagellar transport protein 122 homolog;SPG;WDR10p;WDR140;CED;WD repeat domain 10;WDR10;WD repeat-containing protein 10;WD repeat-containing protein 140
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IFT122-14088H | Recombinant Human IFT122, His-tagged | E.coli | Human | His | 1-359a.a. | |
| IFT122-12147Z | Recombinant Zebrafish IFT122 | Mammalian Cells | Zebrafish | His |
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| IFT122-8047M | Recombinant Mouse IFT122 Protein | Mammalian Cells | Mouse | His |
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| IFT122-5276HCL | Recombinant Human IFT122 293 Cell Lysate | HEK293 | Human | Non |
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| IFT122-4448M | Recombinant Mouse IFT122 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| IFT122-4448M-B | Recombinant Mouse IFT122 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
IFT122 involved in several pathways and played different roles in them. We selected most pathways IFT122 participated on our site, such as Assembly of the primary cilium,Hedgehog off state,Intraflagellar transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFT122 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of the primary cilium | CLUAP1,IFT74,TTC30A,BBS10,HSPB11,CP110,DYNLL2B,DYNC1H1,CCDC123,NEDD1 |
| Signaling by Hedgehog | EVC2,DISP2,GPR161,EFCAB7,RPGRIP1L,BOC,INTU,WDR35,DZIP1,TULP3 |
| Organelle biogenesis and maintenance | MRPL39,MRRF,MRPL49,TFB2M,DYNLRB1,IFT22,MRPS27,IFT52,TNPO1,IFT-20 |
| Intraflagellar transport | IFT22,DYNLL2A,TCTEX1D2,DYNLRB1,DYNLL2B,OST4,WDR34,KIFAP3B,DYF-1,IFT46 |
| Hedgehog off state | WDR19,BBS13,KIF7,MKS1,KIF3A,TULP3,GPR161,IFT52,OFD1,TTC21B |
| Signal Transduction | ARHGAP19,LGR4,DISP2,PENK,FABP11A,MDKB,PTHLHA,GDI1,LIN7B,BCO2A |
Protein Function
IFT122 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFT122 itself. We selected most functions IFT122 had, and list some proteins which have the same functions with IFT122. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SERPING1,DVL1,RPP38,OXA1L,ZNF664-FAM101A,ETV1,CST3,CTSL1,SNTA1,VAMP7 |
Interacting Protein
IFT122 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFT122 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFT122.
ORF;b4dyc6_human;NUDCD3;NUDC;gatA
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References
- Behal, RH; Miller, MS; et al. Subunit Interactions and Organization of the Chlamydomonas reinhardtii Intraflagellar Transport Complex A Proteins. JOURNAL OF BIOLOGICAL CHEMISTRY 287:11689-11703(2012).
