IFITM3
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Official Full Name
interferon induced transmembrane protein 3 -
Overview
The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012] -
Synonyms
IFITM3;interferon induced transmembrane protein 3;1-8U;IP15;DSPA2b;interferon-induced transmembrane protein 3;dispanin subfamily A member 2b;interferon-inducible protein 1-8U
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- HEK293
- Mammalian Cells
- Human Cells
- GST
- mFc
- His
- Non
- Avi
- Fc
Involved Pathway
IFITM3 involved in several pathways and played different roles in them. We selected most pathways IFITM3 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFITM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Interferon alpha/beta signaling | IFIT3,IRF6,IFIT2,XAF1,IRF2,IFI27,IFI35,OASL,SAMHD1,IRF9 |
| Interferon Signaling | IFI6,GBP2,IRF9,TRIM14,TRIM68,GBP4,IRF6,ARIH1,TRIM2,TRIM46 |
| Immune System | MYO9B,NCKAP1,TRIM68,ASB4,IGHM,NCR3LG1,KIF5B,GRAP2B,DEFA1,LRSAM1 |
| Cytokine Signaling in Immune system | PELI1,NRG4,CSHL1,IFI30,CISH,TRIM45,SPNA1,PRLRB,TNIP2,EGR1 |
Protein Function
IFITM3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFITM3 itself. We selected most functions IFITM3 had, and list some proteins which have the same functions with IFITM3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KPNA2,THBS4,CTRC,DDX19A,ABT1,RNF220,UGGT2,TMEM30A,C9orf16,RAMP2 |
Interacting Protein
IFITM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFITM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFITM3.
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References
- Nakajima, A; Ibi, D; et al. Induction of interferon-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes. EUROPEAN JOURNAL OF PHARMACOLOGY 745:166-175(2014).
- Wrensch, F; Winkler, M; et al. IFITM Proteins Inhibit Entry Driven by the MERS-Coronavirus Spike Protein: Evidence for Cholesterol-Independent Mechanisms. VIRUSES-BASEL 6:3683-3698(2014).
