IDH3G
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Official Full Name
isocitrate dehydrogenase 3 (NAD+) gamma -
Overview
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. -
Synonyms
IDH3G;isocitrate dehydrogenase 3 (NAD+) gamma;isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial;mitochondrial;H IDHG;H-IDHG;IDH gamma;IDH3G_HUMAN;Isocitrate dehydrogenase [NAD] subunit gamma;Isocitric dehydrogenase;Isocitric dehydrogenase subunit gamma;NAD (H) specific isocitrate dehydrogenase gamma subunit;NAD(+) specific ICDH;NAD(+)-specific ICDH;NAD(+)-specific ICDH subunit gamma;NAD+ specific ICDH;OTTHUMP00000025984;OTTHUMP00000025985;OTTHUMP00000025987;OTTHUMP00000025988;OTTHUMP00000214764;IDH-gamma;NAD+-specific ICDH;NAD (H)-specific isocitrate dehydrogenase gamma subunit;isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, gamma subunit
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- SUMO
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IDH3G-1324H | Recombinant Human Isocitrate Dehydrogenase 3 (NAD+) Gamma, His-tagged | E.coli | Human | His |
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| IDH3G-2471Z | Recombinant Zebrafish IDH3G | Mammalian Cells | Zebrafish | His |
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| IDH3G-28079TH | Recombinant Human IDH3G | Wheat Germ | Human | Non | 393 amino acids |
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| IDH3G-28927TH | Recombinant Human IDH3G, His-tagged | E.coli | Human | His | 354 amino acids |
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| IDH3G-7988M | Recombinant Mouse IDH3G Protein | Mammalian Cells | Mouse | His |
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| IDH3G-5302HCL | Recombinant Human IDH3G 293 Cell Lysate | HEK293 | Human | Non |
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| IDH3G-5303HCL | Recombinant Human IDH3G 293 Cell Lysate | HEK293 | Human | Non |
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| IDH3G-252HF | Recombinant Full Length Human IDH3G Protein | In Vitro Cell Free System | Human | Full L. 393 amino acids |
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| IDH3G-3064H | Recombinant Human IDH3G protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 40-393aa |
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| IDH3G-4412M | Recombinant Mouse IDH3G Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| IDH3G-4412M-B | Recombinant Mouse IDH3G Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
IDH3G involved in several pathways and played different roles in them. We selected most pathways IDH3G participated on our site, such as Citrate cycle (TCA cycle),Metabolic pathways,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH3G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ETNK2,PTGS1,PYCR1B,APIP,ADH6,AMPD1,GPT2,REV3L,CYP2P7,PIGS |
| Carbon metabolism | HADHAB,PRPS1L1,MUT,OGDH,FBP1A,ackA,HAO1,IDH1,ENO1A,ALDOA |
| -Oxocarboxylic acid metabolism | GOT2A,IDH3A,GPT,ACY1,GOT2B,GPT2L,BCAT2,ACO2,AADAT,IDH1 |
| Biosynthesis of amino acids | GLULB,ALDOCA,ARG1,pykF,TPI1,TKTB,MAT2AL,ENO1A,TKTL1,PHGDH |
| Citrate cycle (TCA cycle) | CS,OGDHL,SDHDB,DLST,SUCLG1,MDH2,SDHB,PCK1,PDHB,DLDH |
Protein Function
IDH3G has several biochemical functions, for example, ATP binding,NAD binding,isocitrate dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH3G itself. We selected most functions IDH3G had, and list some proteins which have the same functions with IDH3G. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| isocitrate dehydrogenase (NAD+) activity | IDH3B,IDH3A |
| NAD binding | IDH3B,DLD,GRHPR,BDH2,GLYR1,ME2,CYB5R3,ADH4,AOX1,GPD1 |
| ATP binding | LIG4,MAT2AA,NLRC5,CDK2,SGK2A,MST1R,KIF25,MYO7B,SIK2,PRKCD |
| magnesium ion binding | SPHK1,ATP9A,RPS6KA2,EYA2,GEM,HACL1,ENO1A,ADPRH,STK4,PGM1 |
Interacting Protein
IDH3G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH3G here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH3G.
IDH3A;adp;MYC
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References
- Bzymek, KP; Colman, RF; et al. Role of alpha-Asp(181), beta-Asp(192), and gamma-Asp(190) in the distinctive subunits of human NAD-specific isocitrate dehydrogenase. BIOCHEMISTRY 46:5391-5397(2007).
- Dal Monego, S; Colitti, M; et al. Evaluation of gene expression profiles of pig skeletal muscle in response to energy content of the diets using human microarrays. ITALIAN JOURNAL OF ANIMAL SCIENCE 6:45-59(2007).
