IDH3B
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Official Full Name
isocitrate dehydrogenase 3 (NAD+) beta -
Overview
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. NADP-specific isocitrate dehydrogenase (ICDH). -
Synonyms
IDH3B;isocitrate dehydrogenase 3 (NAD+) beta;isocitrate dehydrogenase [NAD] subunit beta, mitochondrial;mitochondrial;FLJ11043;H-IDHB;IDH3B_HUMAN;Isocitrate dehydrogenase [NAD] subunit beta;isocitrate dehydrogenase 3, beta subunit;Isocitric dehydrogenase;Isocitric dehydrogenase subunit beta;MGC903;NAD(+)-specific ICDH;NAD(+)-specific ICDH subunit beta;NAD+-specific isocitrate dehydrogenase b subunit;NAD+-specific isocitrate dehydrogenase beta;OTTHUMP00000030023;OTTHUMP00000030024;RP46;NAD+-specific ICDH;isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, beta subunit;Isocitrate Dehydrogenase (NADP +);Isocitrate Dehydrogenase;IDP;PICD;IDH;IDCD;IDPC;EC 1.1.1.42;Isocitrate dehydrogenase [NADP] cytoplasmic;Cytosolic NADP-isocitrate dehydrogenase;Oxalosuccinate decarboxylase;NADP(+)-specific ICDH;NADP+-specific ICDH;NADP-dependent isocitrate dehydrogenase, cytosolic;NADP-dependent isocitrate dehydrog enase, peroxisomal;isocitrate dehydrogenase 1 (NADP+), soluble;isocitrate dehydrogenase (NADP+);isocitrate dehydrogenase (NADP);oxalsuccinic decarboxylase;isocitrate (NADP) dehydrogenase;isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase;NADP-specific isocitrate dehydrogenase;NADP-linked isocitrate dehydrogenase;NADP-dependent isocitrate dehydrogenase;NADP isocitric dehydrogenase;isocitrate dehydrogenase (NADP-dependent);NADP-dependent isocitric dehydrogenase;triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase;NADP+-linked isocitrate dehydrogenase;IDH (ambiguous);dual-cofactor-specific isocitrate dehydrogenase;IDP1;IDP2;IDP3;isocitrate: NADP+ oxidoreductase (decarboxylating)
Recombinant Proteins
- S.cerevisiae
- Pig
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- Cynomolgus
- Human
- Yeast
- Porcine Heart
- Mammalian Cells
- HEK293
- E.coli
- Non
- His
- His&Fc&Avi
- GST
Involved Pathway
IDH3B involved in several pathways and played different roles in them. We selected most pathways IDH3B participated on our site, such as Citrate cycle (TCA cycle),Metabolic pathways,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Citrate cycle (TCA cycle) | PDHA2,OGDHL,SUCLG1,PCK1,ACO1,SUCLA2,SDHDB,DLDH,IDH1,SDHD |
| Biosynthesis of amino acids | RPIA,GPT2,MAT2A,PRPS1A,BCAT1,MAT2B,MAT2AB,NAGS,PYCR2,ALDOC |
| -Oxocarboxylic acid metabolism | GPT2,AADAT,GOT2,ACY1,IDH3G,GPT,BCAT1,GOT2B,BCAT2,ACO2 |
| Metabolic pathways | POLR2J2,OXSR1,PLCD4,CS,DGKE,ACSBG2,COMTB,OGDHA,HSD17B2,PGLS |
| Carbon metabolism | DLD,PRPS1,CS,HADHA,PFKM,ACAT2,ackA,SUCLA2,AGXTA,GLUD2 |
Protein Function
IDH3B has several biochemical functions, for example, NAD binding,electron carrier activity,isocitrate dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH3B itself. We selected most functions IDH3B had, and list some proteins which have the same functions with IDH3B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| magnesium ion binding | PGM1,TSSK4,IDH1,ZNF143B,INPP1,IDH3G,NT5C1B,ZAK,PRPS1A,PGM3 |
| isocitrate dehydrogenase (NAD+) activity | IDH3A,IDH3G |
| electron carrier activity | CYP1A2,ACOX3,COX5A,SDHB,AOC2,FDX1B,DERL3,GRX2,P4HA2,ETFA |
| NAD binding | IDH1,PHGDH,HADHA,NDUFS2,IDH3A,HSD11B2,TESCA,GPD1A,ME3,NNT |
Interacting Protein
IDH3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH3B here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH3B.
PHLDA3;RAB35;MAPK6;ATXN2;PRMT1;MYC;CLPP
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References
- Guay, C; Joly, E; et al. A Role for Cytosolic Isocitrate Dehydrogenase as a Negative Regulator of Glucose Signaling for Insulin Secretion in Pancreatic beta-Cells. PLOS ONE 8:-(2013).
- Li, HH; Su, JH; et al. Proteomic Investigation of the Sinulariolide-Treated Melanoma Cells A375: Effects on the Cell Apoptosis through Mitochondrial-Related Pathway and Activation of Caspase Cascade. MARINE DRUGS 11:2625-2642(2013).
