IDH2
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Official Full Name
isocitrate dehydrogenase 2 (NADP+), mitochondrial -
Overview
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. -
Synonyms
IDH2;isocitrate dehydrogenase 2 (NADP+), mitochondrial;isocitrate dehydrogenase [NADP], mitochondrial;NADP(+)-specific ICDH;oxalosuccinate decarboxylase;IDH;IDP;IDHM;IDPM;ICD-M;D2HGA2;mNADP-IDH
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Cynomolgus
- Mouse
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- Mammalian cells
- HEK293T
- GST
- His
- Myc&DDK
- Flag
- Non
- His&Fc&Avi
Involved Pathway
IDH2 involved in several pathways and played different roles in them. We selected most pathways IDH2 participated on our site, such as Citrate cycle (TCA cycle),Glutathione metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| -Oxocarboxylic acid metabolism | GOT1,BCAT2,GOT2B,AADAT,ACO2,GPT2,GPT,IDH1,ACO1,BCAT1 |
| Glutathione metabolism | PGD,GSTT2,GSTM4,GPX7,GSTA4,GGT1A,GSTAL,RRM2,GSTP1,GGT5 |
| Peroxisome | ACAA1,NOS2,ACOX3,PEX13,HAO2,AMACR,PAOX,PEX19,SLC25A17,MLYCD |
| Carbon metabolism | PRPS1B,FBP1,MDH1,pykF,GLUD1,PKMA,PGK1,ALDOCB,AMT,MDH2 |
| Metabolic pathways | UQCR11,CHPF2,AMPD3B,SHMT2,MDH1,NADSYN1,ATP6V1E2,RPIA,ATP6V1G1,ATP6V0E1 |
| Citrate cycle (TCA cycle) | FH,DLD,SDHB,DLDH,DLAT,PDHA1A,PDHA1B,SUCLG2,PC,SDHDB |
| Biosynthesis of amino acids | MTR,ASL2,GAPDH,ALDH18A1,PFKL,IDH3A,MAT2A,ALDOCA,OTC,SDSL |
Protein Function
IDH2 has several biochemical functions, for example, NAD binding,isocitrate dehydrogenase (NADP+) activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH2 itself. We selected most functions IDH2 had, and list some proteins which have the same functions with IDH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| isocitrate dehydrogenase (NADP+) activity | IDH1 |
| magnesium ion binding | NT5C3A,ATP8B5,ENOSF1,OPA1,DXO,GEM,ADPRH,HACL1,ENO1B,GTPBP10 |
| NAD binding | GPD1,GPD1C,ME2,DLD,HADHA,GRHPRA,CYB5R3,AOX4,AOX3,LDHB |
Interacting Protein
IDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH2.
PYGL;15-deoxy-delta(12,14;ere_dna;HDAC1;KBTBD7;SIRT4;Mad2l1
Resources
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References
- Kato, Y; et al. Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas. BRAIN TUMOR PATHOLOGY 32:3-11(2015).
- Cryan, JB; Haidar, S; et al. Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas. ONCOTARGET 5:8083-8092(2014).
