ID4

  • Official Full Name

    inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

  • Overview

    This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic;helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently,;the activity of the encoded protein depends on the protein binding partner.

  • Synonyms

    ID4;inhibitor of DNA binding 4, dominant negative helix-loop-helix protein;DNA-binding protein inhibitor ID-4;bHLHb27;class B basic helix-loop-helix protein 27;IDB4

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ID4-14045H Recombinant Human ID4, His-tagged E.coli Human His 1-70a.a.
ID4-2189R Recombinant Rhesus monkey ID4 Protein, His-tagged Mammalian Cells Rhesus macaque His
ID4-28078TH Recombinant Human ID4 Wheat Germ Human Non 161 amino acids
ID4-28592TH Recombinant Human ID4 Wheat Germ Human Non 51 amino acids
ID4-3700Z Recombinant Zebrafish ID4 Mammalian Cells Zebrafish His
ID4-5855C Recombinant Chicken ID4 Mammalian Cells Chicken His
ID4-7982M Recombinant Mouse ID4 Protein Mammalian Cells Mouse His
ID4-5309HCL Recombinant Human ID4 293 Cell Lysate HEK293 Human Non
Id4-1210M Recombinant Mouse Id4 Protein, MYC/DDK-tagged HEK293 Mouse Myc&DDK
ID4-2010R Recombinant Rhesus Macaque ID4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
ID4-2010R-B Recombinant Rhesus Macaque ID4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
ID4-248HF Recombinant Full Length Human ID4 Protein In Vitro Cell Free System Human Full L. 161 amino acids
ID4-4408M Recombinant Mouse ID4 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ID4-4408M-B Recombinant Mouse ID4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ID4-992H Recombinant Human ID4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK

    Involved Pathway

    ID4 involved in several pathways and played different roles in them. We selected most pathways ID4 participated on our site, such as TGF-beta signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ID4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TGF-beta signaling pathway BMP2,GDF7,TGFB1,PPP2CA,BMPR2B,SP1,BMPR2A,BMP8A,ZFYVE9,TGFBR1B
    Signaling pathways regulating pluripotency of stem cells SMAD1,TBX3,NODAL,BMI1,WNT3A,FZD3,FZD5,FZD8,FGF2,PIK3CA

    Protein Function

    ID4 has several biochemical functions, for example, RNA polymerase II transcription factor binding,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ID4 itself. We selected most functions ID4 had, and list some proteins which have the same functions with ID4. You can find most of the proteins on our site.

    Function Related Protein
    protein dimerization activity AHRRB,PEF1,DNM1,NPAS4A,NPAS1,HER11,WWOX,PPP3CA,HER12,POLR1D
    RNA polymerase II transcription factor binding GATA2A,KLF4,ZFPM2A,MEF2A,ZFPM1,TBX3,TOX2,TBX6,Ar,NFATC1
    transcription corepressor activity CBFA2T3,SSX2,E2F7,SKOR1A,E2F8,WNT4,TRIM28,KDM5B,ASXL1,ATF7IP
    protein binding RGS17,RAB9B,HIF1AN,GSE1,NECAB2,BIN2,VWF,CCDC22,HOXB9,SRRT

    Interacting Protein

    ID4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ID4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ID4.

    SRC;NCK1;PLCG1;PIK3R1;CRK;GRB2

    Resources

    References

    • Snyder, AD; Dulin-Smith, AN; et al. Expression Pattern of Id Proteins in Medulloblastoma. PATHOLOGY & ONCOLOGY RESEARCH 19:437-446(2013).
    • Mohebbi, H; Rahimi, R; et al. Immunological responses to four-day of consecutive and non-consecutive circuit resistance exercise. MEDICINA DELLO SPORT 65:485-496(2012).

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