ID3

  • Official Full Name

    inhibitor of DNA binding 3, dominant negative helix-loop-helix protein

  • Overview

    The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts.

  • Synonyms

    ID3;inhibitor of DNA binding 3, dominant negative helix-loop-helix protein;DNA-binding protein inhibitor ID-3;bHLHb25;HEIR 1;helix-loop-helix protein HEIR-1;ID-like protein inhibitor HLH 1R21;class B basic helix-loop-helix protein 25;HEIR-1

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • Zebrafish
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • Non
  • His
  • His&Fc&Avi
  • Flag
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
ID3-28591TH Recombinant Human ID3 Wheat Germ Human Non 83 amino acids
ID3-28926TH Recombinant Human ID3 Wheat Germ Human Non 119 amino acids
ID3-2983R Recombinant Rat ID3 Protein Mammalian Cells Rat His
ID3-6158C Recombinant Chicken ID3 Mammalian Cells Chicken His
ID3-7981M Recombinant Mouse ID3 Protein Mammalian Cells Mouse His
ID3-9433Z Recombinant Zebrafish ID3 Mammalian Cells Zebrafish His
ID3-5310HCL Recombinant Human ID3 293 Cell Lysate HEK293 Human Non
ID3-1132H Recombinant Human ID3 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
ID3-1132H-B Recombinant Human ID3 Protein Pre-coupled Magnetic Beads HEK293 Human
ID3-1176HFL Recombinant Full Length Human ID3 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
Id3-1209M Recombinant Mouse Id3 Protein, MYC/DDK-tagged HEK293 Mouse Myc&DDK
ID3-247HF Recombinant Full Length Human ID3 Protein In Vitro Cell Free System Human Full L. 119 amino acids
ID3-2638R Recombinant Rat ID3 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ID3-2638R-B Recombinant Rat ID3 Protein Pre-coupled Magnetic Beads HEK293 Rat
ID3-4407M Recombinant Mouse ID3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ID3-4407M-B Recombinant Mouse ID3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ID3 involved in several pathways and played different roles in them. We selected most pathways ID3 participated on our site, such as TGF-beta signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ID3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TGF-beta signaling pathway MAPK1,SMURF1,ROCK2B,PPP2R1A,NBL1,BMP7A,SMAD5,BAMBI,RHOAB,PPP2CB
    Signaling pathways regulating pluripotency of stem cells SMAD5,HESX1,WNT9A,ID4,HOXB1,PIK3CB,FZD7,WNT7B,FZD3,WNT16

    Protein Function

    ID3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ID3 itself. We selected most functions ID3 had, and list some proteins which have the same functions with ID3. You can find most of the proteins on our site.

    Function Related Protein
    protein binding DIXDC1,FZD2,ASF1B,NFKBIL2,MID1IP1,ARAP1,CDC27,E2F5,ARHGAP5,SLC25A46

    Interacting Protein

    ID3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ID3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ID3.

    TCF4;TCF3;FAM74A1;TCF12;CNOT3;TCF3;ZNF3;ATF3;CSK;FHL2;ZNF626

    Resources

    References

    • Soldini, D; Georgis, A; et al. The combined expression of VPREB3 and ID3 represents a new helpful tool for the routine diagnosis of mature aggressive B-cell lymphomas. HEMATOLOGICAL ONCOLOGY 32:120-125(2014).
    • Liu, XD; Chen, X; et al. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. NATURE 507:513-+(2014).

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