ICK
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Official Full Name
intestinal cell (MAK-like) kinase -
Overview
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. -
Synonyms
ICK;intestinal cell (MAK-like) kinase;serine/threonine-protein kinase ICK;KIAA0936;LCK2;MGC46090;MRK;hICK;MAK-related kinase;laryngeal cancer kinase 2;serine/threonine protein kinase;ECO
Recombinant Proteins
- Human
- Rat
- Mouse
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- E.coli
- HEK293
- Sf21 Cells
- GST
- Non
- His
- His&T7
- Avi&Fc&His
Involved Pathway
ICK involved in several pathways and played different roles in them. We selected most pathways ICK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ICK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ICK has several biochemical functions, for example, ATP binding,cyclin-dependent protein serine/threonine kinase activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ICK itself. We selected most functions ICK had, and list some proteins which have the same functions with ICK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| magnesium ion binding | PRPS1A,PRPS1,ADSS,NEK6,WEE2,FAN1,COMTA,HPRT1,RPS6KA2,OPA1 |
| protein serine/threonine kinase activity | NEK9,DYRK2,DAPK3,GM4922,MAPK12,PRKDC,NEK5,SNRKB,BUB1B,TP53RK |
| ATP binding | MARK3,FRK,RFK,MYO9B,CAMK2B,RPS6KB2,MAP2K2A,CDC34,MYO1C,MCCC2 |
| protein binding | FYN,FAM60A,SPINLW1,TGFA,PILRB,JAM2,XRCC3,C18orf1,TXNRD2,DERL2 |
| cyclin-dependent protein serine/threonine kinase activity | MOK,CDK12,CDK7,STK30,CDK9,CDKL5,NAT1,CDK14,CDK10,CDK5R1 |
Interacting Protein
ICK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICK here. Most of them are supplied by our site. Hope this information will be useful for your research of ICK.
HSP90AB1;SMAD1;TP53;MCM7;PPP2CB;CPSF1;NUP188;PSMD1
Resources
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References
- Vincent, M; Teppaz, G; et al. Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse. MABS 6:1026-1037(2014).
- Vincent, M; Bessard, A; et al. Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency. INTERNATIONAL JOURNAL OF CANCER 133:757-765(2013).
