IBTK
-
Official Full Name
inhibitor of Bruton agammaglobulinemia tyrosine kinase -
Overview
Brutons tyrosine kinase (Btk) is a member of the Btk/Tec family of cytoplasmic tyrosine kinases. Like other Btk family members, it contains a pleckstrin homology (PH) domain and Src homology SH3 and SH2 domains. Btk plays an important role in B cell devel -
Synonyms
IBTK;inhibitor of Bruton agammaglobulinemia tyrosine kinase;Bruton agammaglobulinemia tyrosine kinase inhibitor , BTKI;inhibitor of Bruton tyrosine kinase;DKFZP564B116;BTK-binding protein;inhibitor of Brutons tyrosine kinase;inhibitor of Brutons ty
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Sf9 Cells
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IBTK-1370H |
Active Recombinant Human BTK, His-tagged
|
Sf9 Cells | Human | His | Full length |
|
| IBTK-608C | Recombinant Cynomolgus IBTK Protein, His-tagged | Mammalian Cells | Cynomolgus | His |
|
|
| IBTK-7967M | Recombinant Mouse IBTK Protein | Mammalian Cells | Mouse | His |
|
|
| IBTK-5317HCL | Recombinant Human IBTK 293 Cell Lysate | HEK293 | Human | Non |
|
|
| IBTK-354C | Recombinant Cynomolgus Monkey IBTK Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
|
|
| IBTK-354C-B | Recombinant Cynomolgus Monkey IBTK Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
|
||
| IBTK-4401M | Recombinant Mouse IBTK Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| IBTK-4401M-B | Recombinant Mouse IBTK Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
IBTK involved in several pathways and played different roles in them. We selected most pathways IBTK participated on our site, such as BCR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IBTK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BCR signaling pathway | PAG1,CSK,POU2F2,MAP4K1,MALT1,DOK1,NETO2,CSNK2A1 |
Protein Function
IBTK has several biochemical functions, for example, protein kinase binding,protein tyrosine kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IBTK itself. We selected most functions IBTK had, and list some proteins which have the same functions with IBTK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine kinase inhibitor activity | GNB2L1,FGFR1OP |
| protein kinase binding | BAG5,CRY1,SLC12A5,LATS1,SMAD1,TCF7L2,EPHA1,CCNL1,CDK5RAP2,SV2A |
Interacting Protein
IBTK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IBTK here. Most of them are supplied by our site. Hope this information will be useful for your research of IBTK.
BTK;CD2BP2;RGS2;SNRPN;EIF4A2;PPP1CA;hemC;LAMTOR3;POP7;MSL1;NOP56;SRP72;RPLP1;RPLP0;RPS3;Sars;RFC4;RFC1;RFC3
Resources
Related Services
Related Products
References
- Spatuzza, C; Schiavone, M; et al. Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk. NUCLEIC ACIDS RESEARCH 36:4402-4416(2008).
