HVCN1
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Official Full Name
hydrogen voltage-gated channel 1 -
Overview
This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system.;Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process;facilitates antibody production. This same channel protein, however, can also regulate functions in other cells;including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HVCN1;hydrogen voltage-gated channel 1;voltage-gated hydrogen channel 1;Hv1;MGC15619;voltage sensor domain only protein;VSOP;voltage sensor domain-only protein
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Mus musculus
- zebrafish
- Xenopus laevis
- Ciona Intestinalis
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
HVCN1 involved in several pathways and played different roles in them. We selected most pathways HVCN1 participated on our site, such as Fertilization,Reproduction,Sperm Motility And Taxes, which may be useful for your reference. Also, other proteins which involved in the same pathway with HVCN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Reproduction | ADAM20,TMEM146,ADAM30,CATSPERG1,IZUMO1,IZUMO4,CATSPER1,CATSPERB,CATSPER2,ADAM2 |
| Sperm Motility And Taxes | TMEM146,CATSPERB,CATSPERG2,CATSPER2,CATSPER3,CATSPER1,CATSPERG1 |
| Fertilization | ADAM20,ZP3,CATSPERG2,CATSPER3,ADAM30,OVGP1,CATSPER1,Acr,IZUMO4,ZP2 |
Protein Function
HVCN1 has several biochemical functions, for example, voltage-gated cation channel activity,voltage-gated proton channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HVCN1 itself. We selected most functions HVCN1 had, and list some proteins which have the same functions with HVCN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated proton channel activity | NOX1 |
| voltage-gated cation channel activity | GRIN2A,GRIN1,PKD2,GRIK1 |
Interacting Protein
HVCN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HVCN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HVCN1.
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References
- Sasaki, M; Tojo, A; et al. Autoimmune disorder phenotypes in Hvcn1-deficient mice. BIOCHEMICAL JOURNAL 450:295-301(2013).
- Demaurex, N; El Chemaly, A; et al. Physiological roles of voltage-gated proton channels in leukocytes. JOURNAL OF PHYSIOLOGY-LONDON 588:4659-4665(2010).
- Capasso, M; Bhamrah, MK; et al. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. NATURE IMMUNOLOGY 11:265-U12(2010).
