HUWE1

  • Official Full Name

    HECT, UBA and WWE domain containing 1

  • Overview

    This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.

  • Synonyms

    HUWE1;HECT, UBA and WWE domain containing 1;E3 ubiquitin-protein ligase HUWE1;Ib772;KIAA0312;UREB1;UBA and WWE domain-containing protein 1;ARF binding protein 1;ARF BP1;ARF-binding protein 1;ARF-BP1;E3 ubiquitin protein ligase HUWE1;HECT;HECT UBA and WWE domain containing protein 1;HectH9;Homologous to E6AP carboxyl terminus homologous protein 9;HUWE;HUWE1_HUMAN;KIAA1578;Large structure of UREB1;LASU1;Mcl 1 ubiquitin ligase E3;Mcl-1 ubiquitin ligase E3;MULE;Upstream regulatory element-binding protein 1;URE B1;URE-B1;URE-binding protein 1;UREB 1;OTTHUMP00000023356;OTTHUMP00000023357;BJ-HCC-24 tumor antigen;HECT domain protein LASU1;HECT, UBA;HSPC272

Recombinant Proteins

  • Human
  • Rhesus macaque
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • E. coli
  • GST
  • His
  • Avi
  • Fc
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
HUWE1-14016H Recombinant Human HUWE1, GST-tagged E.coli Human GST C-term-392a.a.
HUWE1-136H Recombinant Human HUWE1, GST-tagged E.coli Human GST 3760-4374 a.a.
HUWE1-14015H Recombinant Human HUWE1, GST-tagged Wheat Germ Human GST
HUWE1-2179R Recombinant Rhesus monkey HUWE1 Protein, His-tagged Mammalian Cells Rhesus macaque His
HUWE1-2000R Recombinant Rhesus Macaque HUWE1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
HUWE1-2000R-B Recombinant Rhesus Macaque HUWE1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
HUWE1-4016H Recombinant Human HUWE1 protein(4005-4374aa), His&Myc-tagged E.coli Human His&Myc 4005-4374aa
HUWE1-7876H Recombinant Human HUWE1 protein, GST-tagged E. coli Human GST
HUWE1-7877H Recombinant Human HUWE1 protein, His-tagged E. coli Human His

    Involved Pathway

    HUWE1 involved in several pathways and played different roles in them. We selected most pathways HUWE1 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HUWE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Validated targets of C-MYC transcriptional activation CDCA7,PEG10,MINA,SERPINI1,PDCD10,DDX18,LIN28B,NDUFAF2,MYCT1,PRDX3
    Immune System DEFB129,RAPGEF4,CD300LD,CD300LH,CRTAM,IL1RN,EVL,GAN,CD300LF,CISH
    Adaptive Immune System TRIM9,CD200R4,FGF8B,ARIH2,CTSC,MGC174152,KIF4,CD300C,AP2S1,AKT3
    Antigen processing: Ubiquitination &amp UBR1,ASB18,ASB14,TRIM69,TRIM39,ASB9,TRIM11,KLHL21,TRIM63,FBXO17
    p53 pathway TRIM28,E4F1,CSE1L,SMYD2,PPP1R13L,TTC5,KAT8,FBXO11,CSNK1G3,RASSF1
    Proteasome degradation RBCK1,KLHL21,RNF25,TRIM41,FBXO3,TRIM69,RNF144B,ASB11,CMTM2A,DZIP3
    Ubiquitin mediated proteolysis UBE2G1,UBE2E2,CUL1B,PIAS4,TRAF6,UBE2L3,BRCA1,CUL3B,UBE2D2A,PML
    presentation CTSS,RNF220,SEC23A,FBXO3,NPEPPS,CMTM2A,GAN,ASB14,RNF6,UBA5
    Class I MHC mediated antigen processing &amp SPSB2,CTSL2,CTSL1,CD207,FBXO17,TRIM63,RNF19B,SEC24A,ASB2,ASB13

    Protein Function

    HUWE1 has several biochemical functions, for example, DNA binding,ligase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HUWE1 itself. We selected most functions HUWE1 had, and list some proteins which have the same functions with HUWE1. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin-protein transferase activity UBE2E1,TRIM17,ARIH2,TRIM5,TOPORS,FBXW2,FBXO22,FLJ11011L,LNX2B,TRIM21
    protein binding SKA3,MINOS1,F11,CASR,FKBP2,ASCC3,UBE2L3,TIMM10,PDGFRB,KIF18A
    ligase activity MARCH11,TRIM58,HLTF,RNF216,HECW1,DTX2,COP1,TRIM38,WWP1,DTX3L
    DNA binding HIST1H2B7,IRF2,ZNF334,PARPBP,DERL3,PDCD5,MXD4,BRPF1,HOXD10A,DICER1
    ubiquitin protein ligase activity CMTM2A,PDZD4,UBE2NB,PJA2,TRIM11,HECTD2,FBXO6,TRIM6,ARIH1L,CCNB1IP1
    poly(A) RNA binding SEC61B,DUSP14,MRPL37,STXBP1,UTP11L,HRSP12,MATR3,RPS16,LSM6,CCBL2

    Interacting Protein

    HUWE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HUWE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HUWE1.

    MCL1;CDKN2A;USP7;TP53;HSPB1;vif

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