HUWE1

  • Official Full Name

    HECT, UBA and WWE domain containing 1

  • Overview

    This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.

  • Synonyms

    HUWE1;HECT, UBA and WWE domain containing 1;E3 ubiquitin-protein ligase HUWE1;Ib772;KIAA0312;UREB1;UBA and WWE domain-containing protein 1;ARF binding protein 1;ARF BP1;ARF-binding protein 1;ARF-BP1;E3 ubiquitin protein ligase HUWE1;HECT;HECT UBA and WWE domain containing protein 1;HectH9;Homologous to E6AP carboxyl terminus homologous protein 9;HUWE;HUWE1_HUMAN;KIAA1578;Large structure of UREB1;LASU1;Mcl 1 ubiquitin ligase E3;Mcl-1 ubiquitin ligase E3;MULE;Upstream regulatory element-binding protein 1;URE B1;URE-B1;URE-binding protein 1;UREB 1;OTTHUMP00000023356;OTTHUMP00000023357;BJ-HCC-24 tumor antigen;HECT domain protein LASU1;HECT, UBA;HSPC272

Recombinant Proteins

  • Human
  • Rhesus macaque
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Avi&Fc&His
  • His&Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
HUWE1-14016H Recombinant Human HUWE1, GST-tagged E.coli Human GST C-term-392a.a.
HUWE1-136H Recombinant Human HUWE1, GST-tagged E.coli Human GST 3760-4374 a.a.
HUWE1-14015H Recombinant Human HUWE1, GST-tagged Wheat Germ Human GST
HUWE1-2179R Recombinant Rhesus monkey HUWE1 Protein, His-tagged Mammalian Cells Rhesus macaque His
HUWE1-2000R Recombinant Rhesus Macaque HUWE1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
HUWE1-2000R-B Recombinant Rhesus Macaque HUWE1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
HUWE1-4016H Recombinant Human HUWE1 protein(4005-4374aa), His&Myc-tagged E.coli Human His&Myc 4005-4374aa

    Involved Pathway

    HUWE1 involved in several pathways and played different roles in them. We selected most pathways HUWE1 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HUWE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System CD300E,GM11711,LCP2A,KIF18A,KIF5B,LRSAM1,SIGLEC9,RAET1E,KLRB1A,DNM1
    presentation UBR1,TRIM63,ASB13,CD207,RNF25,TPP2,SEC23A,UBE2E3,RNF34,UBR2
    Antigen processing: Ubiquitination &amp SH3RF1,PJA1,ASB11,RNF220,UBE2U,HECTD3,UBA5,GAN,UBR2,UBE2V1
    Ubiquitin mediated proteolysis UBA2,NEDD4L,KEAP1,FBXO4,UBE2F,MGRN1B,UBE2D1B,UBE2QL1,SKP1,UBE2Q1
    Class I MHC mediated antigen processing &amp UBE2L6,NPEPPS,TPP2,UBE2F,GAN,RNF25,LRRC41,SPSB1,UBE2J2,ASB10
    Validated targets of C-MYC transcriptional activation DDX18,CDCA7,IREB2,MINA,NDUFAF2,PDCD10,PEG10,MTDH,PRDX3,SERPINI1
    Proteasome degradation RNF182,ASB11,ASB6,MKRN1,KLHL21,UBE2L6,IWS1,TRIM11,UBR1,RNF6
    Immune System TRIM69,MX2,PANX1B,EDA,TNFRSF13C,RNF182,CRCP,UBE2U,CASP4,NLRP3
    p53 pathway DYRK2,SMYD2,E4F1,KAT8,RASSF1,CSNK1G3,CSE1L,FBXO11,TRIM28,TTC5

    Protein Function

    HUWE1 has several biochemical functions, for example, DNA binding,ligase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HUWE1 itself. We selected most functions HUWE1 had, and list some proteins which have the same functions with HUWE1. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin-protein transferase activity TRAF2,HECTD1,FBXL14,DZIP3,TRAF3,RNF115,TRAF7,UBE2T,UBE2K,RBCK1
    DNA binding IFIH1,ZNF670,ZNF571,ZNF484,CERS4,GFI1B,TFDP1A,RFXANK,ABL1,ZNF75A
    ubiquitin protein ligase activity UBR1,CDC34,UBE2NA,HERC4,TRIM32,LRSAM1,FLJ11011L,RAG1,RAG2,NEDD4
    ligase activity RNF34,MARCH6,MARCH5L,BIRC2,TRIM11,MEX3C,PCXB,NAPRT,BIRC7,TRIM68
    protein binding AGTR1,GLE1,RPA3,CCDC53,LGI4,BBC3,CBR2,ARL8A,MYH10,CASP9
    poly(A) RNA binding BCLAF1,KRR1,RPS13,GDI2,HADHB,SYNE1,PRMT1,UBE2O,TRUB2,DNTTIP2

    Interacting Protein

    HUWE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HUWE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HUWE1.

    MCL1;CDKN2A;USP7;TP53;HSPB1;vif

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