HTR2B
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Official Full Name
5-hydroxytryptamine (serotonin) receptor 2B -
Overview
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. -
Synonyms
HTR2B;5-hydroxytryptamine (serotonin) receptor 2B;5-hydroxytryptamine receptor 2B;5 HT(2B);5 HT2B;5 HT 2B;5 hydroxytryptamine (serotonin) receptor 2B;5 hydroxytryptamine 2B receptor;5 hydroxytryptamine receptor 2B;5-HT-2B;5-HT2B;5HT(2B);5HT2B_HUMAN;5HT2F;Htr 2b;NP75 protein;SEROTONIN 5HT2B RECEPTOR;Serotonin receptor 2B;Stomach fundus serotonin receptor;5-HT 2B receptor;OTTHUMP00000164294;5-hydroxytryptamine 2B receptor;5-hydroxytryptamine receptor 2B variant b;5-HT(2B)
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Chicken
- Mouse
- Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)
- Guinea pig
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- In Vitro Cell Free System
- Non
- His
- Flag&His
- Avi&Fc&His
- His&SUMO
- GST
Involved Pathway
HTR2B involved in several pathways and played different roles in them. We selected most pathways HTR2B participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Gap junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Serotonergic synapse | GNG13,KCND2,CYP2J6,CYP2C55,NRAS,SLC6A4,ALOX12E,HTR2A,PLA2G4F,PRKCB |
| Inflammatory mediator regulation of TRP channels | ACCN5,CYP2C55,ACCN4,PIK3R5,PRKCD,PRKCE,PLCG2,NGF,PPP1CB,PRKCB |
| Calcium signaling pathway | SLC8A1B,SLC8A1A,PHKG2,GNA15.4,ERBB3B,CALM3B,PRKCA,F2R,VDAC2,EDNRBA |
| Neuroactive ligand-receptor interaction | EDNRBA,NTSR1,SSTR4,NPBWR2,CSH2,F2RL1.2,TAAR13E,GIPR,FSHB,HTR1AA |
| Gap junction | ITPR1,PRKACBB,PRKACG,PRKACAB,PRKCA,TUBA3E,PLCB2,ADCY2B,CDK1,PDGFAB |
Protein Function
HTR2B has several biochemical functions, for example, G-protein alpha-subunit binding,GTPase activator activity,drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR2B itself. We selected most functions HTR2B had, and list some proteins which have the same functions with HTR2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serotonin binding | HTR1E,HTR1F,HTR2A,HTR1B,MAOA,HTR3A,HTR2C |
| drug binding | PYGL,PDE10A,GLRB,CHRNA2,PDE4D,CHRM2,SIGMAR1,DRD4,SETD6,CHRM3 |
| serotonin receptor activity | HTR1F,HTR3A,HTR3C,HTR6,HTR2A,HTR4,HTR7,HTR5AL,HTR1D,HTR1AB |
| GTPase activator activity | RGS5,ARHGAP5,ARHGAP18,RGS19,RAP1GAP2A,TBC1D5,RGS6,ARHGDIA,LLGL1,GIT2B |
| G-protein alpha-subunit binding | RIC8B,LPAR3,IGF1R,PPP5C,ADRB2,LPAR1,RGS4,CRHR1,F2R,RGS14 |
Interacting Protein
HTR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR2B.
MPDZ
Resources
Research Area
Neurotransmitter Receptors on Endothelial CellsNeurotransmitter G Protein-Coupled Receptors
5-HT Receptors
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References
