HSP90B1
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Official Full Name
heat shock protein 90kDa beta (Grp94), member 1 -
Overview
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in;stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum.;Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a;microRNA gene located within the 5 exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. -
Synonyms
HSP90B1;heat shock protein 90kDa beta (Grp94), member 1;TRA1, tumor rejection antigen (gp96) 1;endoplasmin;GP96;GRP94;GRP-94;gp96 homolog;tumor rejection antigen 1;94 kDa glucose-regulated protein;Tumor rejection antigen-1 (gp96);tumor rejection antigen (gp96) 1;glucose regulated protein, 94 kDa;endothelial cell (HBMEC) glycoprotein;heat shock protein 90 kDa beta member 1;ECGP;TRA1
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Rat
- Canine
- Chicken
- Cynomolgus
- Zebrafish
- HEK293
- E.coli
- Mammalian Cell
- Insect Cell
- Mammalian cells
- HEK293T
- His
- Non
- Myc&DDK
- His&T7
- His&Myc
- Flag
- His&Fc&Avi
Involved Pathway
HSP90B1 involved in several pathways and played different roles in them. We selected most pathways HSP90B1 participated on our site, such as Protein processing in endoplasmic reticulum,PIK-Akt signaling pathway,NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSP90B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | GNG2,RPS6,G6PC3,ANGPT2,MTOR,LAMA5,PKN2,IL3RA,CRTC2,CREB5 |
| Estrogen signaling pathway | GPR30,HSP90AA1,GNAO1,PLCB3,CALML5,SHC2,ITPR3,CREB3L1,PLCB4,GABBR1 |
| NOD-like receptor signaling pathway | TNFAIP3,HSP90AA1.2,MAPK12B,BIRC2,NLRC4,CCL2,IL18,CXCL2,CXCL1,PYDC1 |
| Protein processing in endoplasmic reticulum | DNAJB12,SAR1B,TRAF2,HSPA6,HSP70L,NFE2L2,TXNDC5,ATF6,BAG2,HSPA5 |
| Prostate Cancer | HSP90AA1,ARAF,PIK3CB,INS1,PDGFD,Ar,IGF1,CREB3L2,CPN1,PIK3R1 |
| Pathways in cancer | FGFR3,CBLB,WNT5B,TRAF2,PTK2,WNT9B,RAC3,SMAD4,FZD7,WNT5A |
| Thyroid hormone synthesis | SLC5A5,PRKCA,ATF4,PRKCB,CANX,DUOXA2,ATP1A2,TSHB,ATP1B2,GNAS |
Protein Function
HSP90B1 has several biochemical functions, for example, ATP binding,RNA binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSP90B1 itself. We selected most functions HSP90B1 had, and list some proteins which have the same functions with HSP90B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ARMC8,IL1RL1,SMAD9,TRAPPC3,KCNQ5,HNRPLL,NLK,RXFP1,FAM200A,RAP1A |
| ATP binding | MSH4,ACOT12,MKNK2,OXSR1A,DDR2,PRKCZ,PRKAA2,MYO1H,CHD8,KDR |
| low-density lipoprotein particle receptor binding | APOA5,APOEB,SNX17,CCDC167,AP2M1,APOB,SACS,LRPAP1,PCSK9,CRP |
| RNA binding | SARNP,RPL5,THOC7,DPPA5A,RPL8,DDX17,CPSF1,RDM1,SRP9,ARHGEF28 |
| unfolded protein binding | TOR1A,PDRG1,DNAJB11,PPIB,CLN3,DNAJB1A,HSP104,AIP,CHAF1A,H2-KE2 |
| calcium ion binding | ANXA5B,SYT6,TNNC1A,EMR3,PCDH1G18,NUCB1,ATP2A2,PRRG2,RYR3,TESCB |
| protein phosphatase binding | CDKN1B,FLT4,PPP1R3G,PIK3R1,CTNNB1,STAT3,CDH2,HSF4,JUPA,KCNN4 |
| virion binding | PPIA,PTX3,HIPK2,PVRL1,CLEC4M,TSG101,CD209,APCS |
Interacting Protein
HSP90B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSP90B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSP90B1.
FANCC;PPIB;FOS;SOD2;TNFRSF1B;NR4A1;CHM;RXRB;EEF1D;MDM2;UBA5;SIRT3;EIF2AK3;GAMMAHV.ORF40;GAMMAHV.M9;EGFR;POLR2E
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