HSD3B1
-
Official Full Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 -
Overview
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. -
Synonyms
HSD3B1;hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1;HSD3B, HSDB3;3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1;SDR11E1;short chain dehydrogenase/reductase family 11E;member 1;3 beta-hydroxystero
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Mouse
- Macaca mulatta
- Mus musculus
- Mesocricetus auratus
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
- His&Myc
Involved Pathway
HSD3B1 involved in several pathways and played different roles in them. We selected most pathways HSD3B1 participated on our site, such as Steroid hormone biosynthesis,Metabolic pathways,Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD3B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ovarian steroidogenesis | LDLR,GDF9,INS,CYP2J5,HSD3B2,CYP2J6,ALOX5,IGF1,SCARB1,IGF1R |
| Aldosterone synthesis and secretion | CALM1,CREB5,CALM2,PRKCE,Adcy4,CREB3,LDLR,CREB3L4,CACNA1H,HSD3B5 |
| Steroid hormone biosynthesis | UGT1A9,CYP2D26,HSD17B12A,CYP2C50,CYP2C55,AKR1D1,UGT1A4,HSD17B12B,PPP1R2,CYP2D10 |
| Metabolic pathways | POLR1D,PLA2G2F,TSTA3,NDUFB3,PLCD1A,AGXTA,MAT1A,NME2,SLC33A1,NT5C3A |
Protein Function
HSD3B1 has several biochemical functions, for example, 3-beta-hydroxy-delta5-steroid dehydrogenase activity,steroid delta-isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD3B1 itself. We selected most functions HSD3B1 had, and list some proteins which have the same functions with HSD3B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| steroid delta-isomerase activity | HSD3B6,EBP,HSD3B2 |
| 3-beta-hydroxy-delta5-steroid dehydrogenase activity | HSD3B7,NSDHL,HSD3B5,HSD3B2,HSD3B4,HSD3B6,SDR42E1 |
Interacting Protein
HSD3B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD3B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD3B1.
Resources
Related Services
Related Products
References
- Doi, M; Satoh, F; et al. Isoform-Specific Monoclonal Antibodies Against 3 beta-Hydroxysteroid Dehydrogenase/Isomerase Family Provide Markers for Subclassification of Human Primary Aldosteronism. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E257-E262(2014).
- Chou, YY; Jeng, YM; et al. HSD3B1 Is a Specific Trophoblast-Associated Marker Not Expressed in a Wide Spectrum of Tumors. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 23:343-347(2013).
