HS3ST4
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Official Full Name
heparan sulfate (glucosamine) 3-O-sulfotransferase 4 -
Overview
This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated;glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus;type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. -
Synonyms
HS3ST4;heparan sulfate (glucosamine) 3-O-sulfotransferase 4;heparan sulfate glucosamine 3-O-sulfotransferase 4;3OST4;heparan sulfate 3-O-sulfotransferase 4;heparan sulfate 3-O-sulfotransferase-4;heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4;30ST4;3-OST-4;h3-OST-4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HS3ST4-1971H |
Active Recombinant Human Heparan Sulfate (glucosamine) 3-O-Sulfotransferase 4, His-tagged
|
CHO | Human | His | 184-456 a.a. |
|
| HS3ST4-564H |
Active Recombinant Human HS3ST4 Protein, His-tagged
|
CHO | Human | His | Gly184-Lys456 |
|
| HS3ST4-5054H | Recombinant Human HS3ST4 Protein | Wheat Germ | Human | Non |
|
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| HS3ST4-5055H | Recombinant Human HS3ST4 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| HS3ST4-5085Z | Recombinant Zebrafish HS3ST4 | Mammalian Cell | Zebrafish | His |
|
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| HS3ST4-3698HF | Recombinant Full Length Human HS3ST4 Protein | In Vitro Cell Free System | Human | Full L. 525 amino acids |
|
Involved Pathway
HS3ST4 involved in several pathways and played different roles in them. We selected most pathways HS3ST4 participated on our site, such as Glycosaminoglycan metabolism,HS-GAG biosynthesis,Heparan sulfate/heparin (HS-GAG) metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HS3ST4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| heparan sulfate biosynthesis (late stages) | A4GNT |
| HS-GAG biosynthesis | SLC35D2,GPC1B,HS3ST6,GPC5A,Gpc2,GPC1A,MAPK1IP1L |
| Heparan sulfate/heparin (HS-GAG) metabolism | GPC1B,HPSE,Gpc2,SLC35D2,GPC5A,B4GALT7,GLB1L,GPC1A,B3GAT2,CSPG5B |
| metapathway biotransformation | KCNAB1,NAA40,GAL3ST4,CYP4V2,NAT9,CEACAM21,NAA30,SULT1C2,NAT8,NAT14 |
| Metabolism of carbohydrates | UST,SLC5A4,SLC35B3,SLC25A1A,SLC26A2,FMODA,OMD,CHST14,SLC5A2,B3GAT2 |
| heparan sulfate biosynthesis | A4GNT,MAPK1IP1L |
| Glycosaminoglycan metabolism | UST,B3GNT1,B3GNT2,CSPG5B,HPSE,HAS1,SLC35B3,GLB1L,B3GAT2,SLC35B2 |
| Metabolism | DGAT1B,MED19,COQ6,ISCU,KCNG4,CYP2AD2,ARSH,GLTPD1,CHST9,GYG1A |
Protein Function
HS3ST4 has several biochemical functions, for example, [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HS3ST4 itself. We selected most functions HS3ST4 had, and list some proteins which have the same functions with HS3ST4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity | HS3ST3B1,HS3ST6,HS3ST1,HS3ST5 |
Interacting Protein
HS3ST4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HS3ST4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HS3ST4.
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References
- Brusilovsky, M; Cordoba, M; et al. Genome-Wide siRNA Screen Reveals a New Cellular Partner of NK Cell Receptor KIR2DL4: Heparan Sulfate Directly Modulates KIR2DL4-Mediated Responses. JOURNAL OF IMMUNOLOGY 191:5256-5267(2013).
- Pempe, EH; Burch, TC; et al. Substrate specificity of 6-O-endosulfatase (Sulf-2) and its implications in synthesizing anticoagulant heparan sulfate. GLYCOBIOLOGY 22:1353-1362(2012).
