HRH4
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Official Full Name
histamine receptor H4 -
Overview
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] -
Synonyms
HRH4;histamine receptor H4;H4;H4R;BG26;HH4R;AXOR35;GPRv53;GPCR105;histamine H4 receptor;SP9144;pfi-013;G-protein coupled receptor 105
Recombinant Proteins
- Rat
- Human
- Cynomolgus
- Mouse
- Mus musculus
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- Protein Conjugation
- His
- GST
- Avi
- Fc
Involved Pathway
HRH4 involved in several pathways and played different roles in them. We selected most pathways HRH4 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HRH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | DRD1B,TAAR8B,GNRHR,OXTR,GRM1,OPRD1A,HTR1A,CHRNB1,GRIN3A,THRB |
Protein Function
HRH4 has several biochemical functions, for example, histamine binding,histamine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HRH4 itself. We selected most functions HRH4 had, and list some proteins which have the same functions with HRH4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histamine binding | HRH3,HRH1 |
| histamine receptor activity | HRH3,HTR6,HRH1,HRH2 |
Interacting Protein
HRH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HRH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HRH4.
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References
- Schneider, EH; Neumann, D; et al. Modulation of behavior by the histaminergic system: Lessons from HDC-, H3R- and H4R-deficient mice. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 47:101-121(2014).
- Yu, B; Shao, Y; et al. Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus. BRITISH JOURNAL OF DERMATOLOGY 163:935-940(2010).
