HRH3
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Official Full Name
histamine receptor H3 -
Overview
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. -
Synonyms
HRH3;histamine receptor H3;histamine H3 receptor;GPCR97;H3R;G protein-coupled receptor 97;G-protein coupled receptor 97;HH3R
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Human
- Mouse
- Guinea pig
- Rat
- Mus musculus
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- His
- GST
- His&Fc&Avi
- Non
- GFP
Involved Pathway
HRH3 involved in several pathways and played different roles in them. We selected most pathways HRH3 participated on our site, such as Amine ligand-binding receptors,Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with HRH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCRs, Class A Rhodopsin-like | GPR32,GPR45,GPR17,GPR20,AGTR2,ADORA1,OPN1MW,SSTR2,ACKR4,CCBP2 |
| GPCR downstream signaling | TAC2,HEBP1,CHRM5,TAE1,PIK3R6,S1PR1,OR7D2,S1PR5B,CNR2,OBSCN |
| GPCR ligand binding | OPN1MW,UTS2D,ADRA2B,RAMP1,OXER1,FPR-RS4,GPR4,CCRL2,DRD3,ANXA1 |
| G alpha (i) signalling events | RLN3A,FPR-RS4,OXER1,PYY,TAS2R16,ANXA1A,ANXA1,NMS,PPY,LPAR1 |
| Amine ligand-binding receptors | ADRB1,DRD1,ADRA2B,CHRM3,ADRB2,CHRM4,ADRA2A,DRD2,DRD4,ADRa1A |
| Monoamine Transport | SYN1,DBH,FBXO32,UNC13B,TGFB1I1,TPH2,SCAMP2 |
| Class A/1 (Rhodopsin-like receptors) | LTB4R,LPAR2A,CCR5,SSTR5,RXFP2,SSTR2,NTS,CCR6,LPAR5A,PTGDR2 |
Protein Function
HRH3 has several biochemical functions, for example, histamine binding,histamine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HRH3 itself. We selected most functions HRH3 had, and list some proteins which have the same functions with HRH3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histamine receptor activity | HTR6,HRH1,HRH2,HRH4 |
| histamine binding | HRH4,HRH1 |
Interacting Protein
HRH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HRH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HRH3.
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