HOXB5
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Official Full Name
homeobox B5 -
Overview
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. -
Synonyms
HOXB5;homeobox B5;homeo box B5 , HOX2, HOX2A;homeobox protein Hox-B5;HGNC:5116;HHO.C10;Homeo box 2A;Homeo box B5;Homeobox 2A;Homeobox protein HHO.C10;Homeobox protein Hox B5;Homeobox protein Hox-2A;Homeobox protein HoxB5;Homeobox protein Hu-1;Homeobox2A;HomeoboxB5;HOX 2;Hox 2.1;HOX 2A;HOX B5;HOX2;Hox2.1;HOX2A;HOXB 5;HU 1;HU1;HXB5_HUMAN;HU-1
Recombinant Proteins
- Chicken
- Human
- Cynomolgus
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HOXB5-2209C | Recombinant Chicken HOXB5 | Mammalian Cell | Chicken | His |
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| HOXB5-28512TH | Recombinant Human HOXB5 | Wheat Germ | Human | Non | 98 amino acids |
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| HOXB5-4962H | Recombinant Human HOXB5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HOXB5-593C | Recombinant Cynomolgus HOXB5 Protein, His-tagged | Mammalian Cell | Cynomolgus | His |
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| HOXB5-5422HCL | Recombinant Human HOXB5 293 Cell Lysate | HEK293 | Human | Non |
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| HOXB5-1896H | Recombinant Human HOXB5 Protein, His-tagged | E.coli | Human | His |
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| HOXB5-339C | Recombinant Cynomolgus Monkey HOXB5 Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
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| HOXB5-339C-B | Recombinant Cynomolgus Monkey HOXB5 Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
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| HOXB5-3718HF | Recombinant Full Length Human HOXB5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 269 amino acids |
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Involved Pathway
HOXB5 involved in several pathways and played different roles in them. We selected most pathways HOXB5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HOXB5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
HOXB5 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding,protein binding,transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXB5 itself. We selected most functions HOXB5 had, and list some proteins which have the same functions with HOXB5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MORN3,AGO2,LEF1,GPR85,CENPL,SLC4A1A,JUP,CNKSR3,KCNJ15,TUFT1 |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | CDX1,TARDBP,ZEB2,HCFC1,SIX3,REL,POU4F1,MEOX2,PROP1,NFE2L1 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | RELA,ATF2,BACH1,NFE2L1,FLI1,ESRRB,NR2F6,RUVBL2,TFAP2C,SFPI1 |
Interacting Protein
HOXB5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXB5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXB5.
TRIM23;MAGEA11;CTBP1;CTBP2;MYC
Resources
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References
- Fessner, A; Esser, JS; et al. The transcription factor HoxB5 stimulates vascular remodelling in a cytokine-dependent manner. CARDIOVASCULAR RESEARCH 101:247-255(2014).
- Volpe, MV; Ramadurai, SM; et al. Regulatory Interactions between Androgens, Hoxb5, and TGF beta Signaling in Murine Lung Development. BIOMED RESEARCH INTERNATIONAL :-(2013).
