HOXA3
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Official Full Name
homeobox A3 -
Overview
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
HOXA3;homeobox A3;homeo box A3 , HOX1, HOX1E;homeobox protein Hox-A3;Homeo box 1E;Homeo box A3;Homeobox 1E;Homeobox protein HOX A3;Homeobox protein HOXA3;Homeobox1E;HomeoboxA3;HOX 1;Hox 1.5 like protein;HOX 1E;HOX A3;HOX1;Hox1.5;Hox1.5 like protein;HOX1E;HOXA 3;MGC10155;Hox-1.5-like protein;homeobox protein Hox-1E
Recombinant Proteins
- Human
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli
- Yeast
- GST
- His
- Non
- His&Fc&Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HOXA3-4944H | Recombinant Human HOXA3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HOXA3-6117C | Recombinant Chicken HOXA3 | Mammalian Cell | Chicken | His |
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| HOXA3-7789M | Recombinant Mouse HOXA3 Protein | Mammalian Cell | Mouse | His |
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| HOXA3-5426HCL | Recombinant Human HOXA3 293 Cell Lysate | HEK293 | Human | Non |
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| HOXA3-3627H | Recombinant Human HOXA3 Protein (Met1-Leu443), N-GST tagged | E.coli | Human | GST | Met1-Leu443 |
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| HOXA3-4279M | Recombinant Mouse HOXA3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HOXA3-4279M-B | Recombinant Mouse HOXA3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| HOXA3-4938H | Recombinant Human HOXA3 protein(1-443aa), hFc-tagged | HEK293 | Human | Fc | 1-443aa |
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| HOXA3-6435H | Recombinant Human HOXA3 protein, His-tagged | Yeast | Human | His | 1-443aa |
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Involved Pathway
HOXA3 involved in several pathways and played different roles in them. We selected most pathways HOXA3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HOXA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HOXA3 has several biochemical functions, for example, HMG box domain binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXA3 itself. We selected most functions HOXA3 had, and list some proteins which have the same functions with HOXA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RSL24D1,OPRL1,SLC22A3,PDLIM7,TIFA,NCOA5,HINFP,ACSS1,RAP1B,MAPK15 |
| transcription factor activity, sequence-specific DNA binding | FLI1B,REST,NEUROG1,GBX2,PPARDB,NFE2L2B,TFAP2B,ZNF461,ZNF234,HOXC5 |
| HMG box domain binding | MEOX1,SP1,EGR2,PRRX1,UTF1,GATA3,OLIG2,HOXC4,PAX3,JUN |
| sequence-specific DNA binding | HNF4G,NR0B1,HOXB13,GBX1,HOXB3A,TEFA,VDRA,SALL1A,FOXO1B,IRX4A |
Interacting Protein
HOXA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXA3.
SEC23B;ARPC3;TERF1;ZDHHC17;TINF2;POT1
Resources
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References
- Calonge, WM; Martinez, L; et al. Expression of homeotic genes Hoxa3, Hoxb3, Hoxd3 and Hoxc4 is decreased in the lungs but not in the hearts of adriamycin-exposed mice. PEDIATRIC SURGERY INTERNATIONAL 23:419-424(2007).
- Chisaka, O; Kameda, Y; et al. Hoxa3 regulates the proliferation and differentiation of the third pharyngeal arch mesenchyme in mice. CELL AND TISSUE RESEARCH 320:77-89(2005).
- Kameda, Y; Watari-Goshima, N; et al. Disruption of the Hoxa3 homeobox gene results in anomalies of the carotid artery system and the arterial baroreceptors. CELL AND TISSUE RESEARCH 311:343-352(2003).
