HNF1A

  • Official Full Name

    HNF1 homeobox A
  • Overview

    LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1), TCF3, and TCF4 (1). LEF1 and TCF1 were originally iden
  • Synonyms

    HNF1A;HNF1 homeobox A;MODY3, TCF1, transcription factor 1, hepatic;LF B1, hepatic nuclear factor (HNF1), albumin proximal factor;hepatocyte nuclear factor 1-alpha;HNF1;LFB1;HNF-1-alpha;albumin proximal factor;hepatic nuclear factor 1;transcript

Recombinant Proteins

  • Chicken
  • Rat
  • Human
  • Mouse
  • Zebrafish
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • E.coli
  • His
  • GST
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
HNF1A-2372C Recombinant Chicken HNF1A Mammalian Cells Chicken His
HNF1A-2876R Recombinant Rat HNF1A Protein Mammalian Cells Rat His
HNF1A-4891H Recombinant Human HNF1A Protein, GST-tagged Wheat Germ Human GST 532-631 a.a.
HNF1A-7750M Recombinant Mouse HNF1A Protein Mammalian Cells Mouse His
HNF1A-9486Z Recombinant Zebrafish HNF1A Mammalian Cells Zebrafish His
HNF1A-5461HCL Recombinant Human HNF1A 293 Cell Lysate HEK293 Human Non
Hnf1a-1633M Recombinant Mouse Hnf1a Protein, His&GST-tagged E.coli Mouse GST&His Asp56-Arg321
HNF1A-2249H Recombinant Human HNF1A Protein, His-tagged E.coli Human His Glu71-Arg271
HNF1A-2531R Recombinant Rat HNF1A Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
HNF1A-2531R-B Recombinant Rat HNF1A Protein Pre-coupled Magnetic Beads HEK293 Rat
Hnf1a-3417M Recombinant Mouse Hnf1a Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
HNF1A-4253M Recombinant Mouse HNF1A Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
HNF1A-4253M-B Recombinant Mouse HNF1A Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    HNF1A involved in several pathways and played different roles in them. We selected most pathways HNF1A participated on our site, such as Signaling pathways regulating pluripotency of stem cells,Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells BMI1,INHBE,FZD8,GRB2,SMARCAD1,PCGF1,LIF,WNT16,SOX2,Fzd4
    Maturity onset diabetes of the young INS2,FOXA3,RFX6,HES1,PAX4,PKLR,INS1,INS,MNX1,IAPP

    Protein Function

    HNF1A has several biochemical functions, for example, DNA binding,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HNF1A itself. We selected most functions HNF1A had, and list some proteins which have the same functions with HNF1A. You can find most of the proteins on our site.

    Function Related Protein
    protein dimerization activity MNT,ASCL1A,EBF1,NUP210,SRFB,OLIG1,HER4.2,ASCL2,GGN,SCXA
    DNA binding NKX1.2LA,WRNIP1,ABL1,ZSCAN2,ZNF469,ZNF468,TBX1,DEM1,ZFP110,TRIM26
    transcription factor activity, sequence-specific DNA binding ZNF548,RARGA,HDAC1,ZGPAT,ESRRGB,ZNF567,STAT1B,DMRT1,KDM5A,FOXH1
    protein homodimerization activity DAXX,MAPK4,ACHE,TIMELESS,WHRN,PAFAH1B1,BAX,PRDX4,RBM11,TIRAP
    protein heterodimerization activity RXRA,PANX2,ATF2,H2AFVB,MEIS1,DDX1,CREB3L3,PAFAH1B2,SOX6,UNC13A
    protein binding ITGAM,ZBTB5,SCAMP2,TTK,KDM6B,MAP6,NAA10,YBX1,CHCHD1,TNFRSF1A
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding SOX11,JUNB,NFIA,NR1H4,NFIB,CREB3L2,SMAD2,MITFA,MYC,NEUROD6
    transcription regulatory region DNA binding PAX2,TFAP4,CREB3L2,ZFP513,IKZF2,ASH2L,PRDM5,CTCFL,ETV5,PHB

    Interacting Protein

    HNF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HNF1A.

    DYRK1B;PCBD1;PCBD2;PROX1;RNF14;angt_human_apre-2_dna-probe;SNRPA1;CALM1;FABP5;RYR3

    Resources

    References

    • Simaite, D; Kofent, J; et al. Recessive Mutations in PCBD1 Cause a New Type of Early-Onset Diabetes. DIABETES 63:3557-3564(2014).
    • Shankar, RK; Ellard, S; et al. Digenic heterozygous HNF1A and HNF4A mutations in two siblings with childhood-onset diabetes. PEDIATRIC DIABETES 14:535-538(2013).

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