HMGN3
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Official Full Name
high mobility group nucleosomal binding domain 3 -
Overview
Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HMGN3;high mobility group nucleosomal binding domain 3;thyroid hormone receptor interactor 7 , TRIP7;high mobility group nucleosome-binding domain-containing protein 3;DKFZp686E20226;FLJ42187;HMGN3_HUMAN;OTTHUMP00000016772;OTTHUMP00000016773;PNAS 24;PNAS 25;PNAS24;PNAS25;Thyroid hormone receptor interacting protein 7;Thyroid receptor-interacting protein 7;TR-interacting protein 7;TRIP 7;TRIP-7;TRIP7;PNAS-24;PNAS-25
Recombinant Proteins
- Chicken
- Zebrafish
- Rat
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
HMGN3 involved in several pathways and played different roles in them. We selected most pathways HMGN3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HMGN3 has several biochemical functions, for example, nucleosomal DNA binding,thyroid hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGN3 itself. We selected most functions HMGN3 had, and list some proteins which have the same functions with HMGN3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| thyroid hormone receptor binding | MED24,MED13,NR0B2,NCOA3,GAS2L1,TAF11,MED4,MED16,PRMT2,THRAP3 |
| nucleosomal DNA binding | RCC1,H3F3A,H2AFZ,HMGN2,HMGA2,H2AFY,HMGN1,H3F3C,HMGN4,HNRNPC |
Interacting Protein
HMGN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGN3.
SRPK2;SRPK1;GRB2;SMAD2;TERF1;TERF2;ycdQ;TERF2IP;p27958-pro_0000037566;Csnk1d
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References
- Chekmareva, NY; Sotnikov, SV; et al. Environmental manipulations generate bidirectional shifts in both behavior and gene regulation in a crossbred mouse model of extremes in trait anxiety. FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8:-(2014).
- Kugler, JE; Horsch, M; et al. High Mobility Group N Proteins Modulate the Fidelity of the Cellular Transcriptional Profile in a Tissue- and Variant-specific Manner. JOURNAL OF BIOLOGICAL CHEMISTRY 288:16690-16703(2013).
