HMGCL
-
Official Full Name
3-hydroxymethyl-3-methylglutaryl-CoA lyase
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Insect Cells
- In Vitro Cell Free System
- His
- GST
- T7
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
HMGCL involved in several pathways and played different roles in them. We selected most pathways HMGCL participated on our site, such as Synthesis and degradation of ketone bodies,Valine, leucine and isoleucine degradation,Butanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGCL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Butanoate metabolism | ACSM2,ACSM3,ACSM4,ALDH5A1,GAD2,HADHA,HADHAA,ACAT1,HADH,EHHADH |
| Valine, leucine and isoleucine degradation | AOX1,OXCT2A,ACAA1A,ALDH6A1,AUH,HIBADHB,ALDH2.1,ACAT1,PCCA,DLDH |
| Metabolic pathways | KYNU,LTC4S,ALDH3A2,CKMT1B,DAO.1,SMS,NDUFA1,RPIA,PI4K2B,NMNAT2 |
| Synthesis and degradation of ketone bodies | BDH2,BDH1,OXCT2B,OXCT1,OXCT1B,OXCT1A,HMGCLL1,OXCT2,OXCT2A,HMGCS1 |
| Peroxisome | HACL1,XDH,ACSL5,HSD17B4,GSTK1,PEX11B,SOD1,PEX19,ACSL1,DDO |
Protein Function
HMGCL has several biochemical functions, for example, carboxylic acid binding,fatty-acyl-CoA binding,hydroxymethylglutaryl-CoA lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGCL itself. We selected most functions HMGCL had, and list some proteins which have the same functions with HMGCL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fatty-acyl-CoA binding | ACAD9,ACBD5B,GCDHB,ACBD3,PECI,HADHA,DBIL5,ACOX1,ACBD5,ETFA |
| metal ion binding | PTGS1,PDE7A,CA4B,ZEB2B,GZF1,NOB1,ADSSL,PLA2G2F,SOBPB,ZNF614 |
| protein homodimerization activity | CCBL1,AGXT,EIF2AK3,ADH1,UNC13A,E2F8,ZBTB1,TRIM8,NOS2,ATP2A1 |
| carboxylic acid binding | GOT1,HIF1AN,GRHPR,AKR1C21,AKR1C2,PCK1 |
| hydroxymethylglutaryl-CoA lyase activity | HMGCLL1 |
| receptor binding | GUSB,PVRL1A,PDGFRB,LRP6,IZUMO1,FGF11,CCDC129,PVRL2L,FZD1,MLYCD |
| manganese ion binding | GLUL,MRE11A,MTPAP,PPM1B,TDP2,GYLTL1B,PPM1AB,FAM20C,ABL1,LAP3 |
| magnesium ion binding | PKM,STK36,TESC,GEM,GTPBP10,ATP8B5,PTENA,ENO1A,NT5C1AA,DCTPP1 |
Interacting Protein
HMGCL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGCL here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGCL.
DNAJA1;GTF2B;HES1;ARL6IP1;q5ngc7_fratt;RNF126;MS4A7;ADAMTS10;SIRT4
Resources
Related Services
Related Products
References
