HMGA2
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Official Full Name
high mobility group AT-hook 2 -
Overview
HMGA2 belongs to the family of high mobility group with AT-hook DNA binding domain. HMGA proteins are considered architectural transcription factors; they do not have direct transcriptional activation capacity, but instead regulate gene expression by chan -
Synonyms
HMGA2;high mobility group AT-hook 2;high mobility group (nonhistone chromosomal) protein isoform I C , HMGIC;high mobility group protein HMGI-C;BABL;LIPO;High-mobility group protein HMGI-C;high mobility group AT-hook protein 2;high-mobility group
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- DDK&Myc
- GST&His
- Avi&Fc&His
Involved Pathway
HMGA2 involved in several pathways and played different roles in them. We selected most pathways HMGA2 participated on our site, such as Transcriptional misregulation in cancer,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | IRS1,PRKCG,PDGFA,ITGA5,MDM2,GLS,EP300,ROCK1,BMI1,VEGFA |
| Transcriptional misregulation in cancer | Bcl2a1b,H3F3A,IL6,IGFBP3,MLF1,ETV6,WHSC1,HIST1H3F,SSX2,ETV4 |
Protein Function
HMGA2 has several biochemical functions, for example, 5-deoxyribose-5-phosphate lyase activity,AT DNA binding,C2H2 zinc finger domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGA2 itself. We selected most functions HMGA2 had, and list some proteins which have the same functions with HMGA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleosomal DNA binding | H1FOO,NSBP1,H3F3B,H3F3A,HMGN2,H2AFY,H2AFZ,HMGN3,RCC1,HMGN1 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | TCF3,REST,HAND1,NKX6,HOXA2,CREBBP,PPARA,NR2C1,NKX6-2,ATF3 |
| transcription factor binding | NKX3-1,RBFOX2,E2F4,SUMO1,NLK,IFI16,HEY1,LMO4,FOXA3,HES1 |
| C2H2 zinc finger domain binding | U2AF2,EHMT2,WT1,GATA1,EHMT1,LEF1,THAP7,TAF9,GATA2,EBF1 |
| AT DNA binding | CRIP1,POU3F4,MEF2C,HMGA1 |
| DNA-(apurinic or apyrimidinic site) lyase activity | HMGA1A,NEIL2,RPS3,NEIL1,APLF,APEX1,HMGA1B,APEX2,NTHL1,HMGA1-RS1 |
| DNA-dependent protein kinase activity | XRCC6BP1,ATM,PRKDC,ALPK2 |
| core promoter binding | HDAC2,E2F1,EP300,NKX2-1,MYOG,KLF4,NKX3,RBMX,HDAC4,XBP1 |
| protein binding | STX4,EIF2AK2,KLRK1,PSMD5,SPZ1,EPS15L1,DPM1,KATNAL1,HNRNPUL1,HSCB |
Interacting Protein
HMGA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGA2.
PRMT6;PRMT1;ssdna_dadts;H2AFX;ATM
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References
- Rudzinski, ER; Anderson, JR; et al. Myogenin, AP2 beta, NOS-1, and HMGA2 Are Surrogate Markers of Fusion Status in Rhabdomyosarcoma A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:654-659(2014).
- Chieffi, P; Chieffi, S; et al. Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: An overview. JOURNAL OF CELLULAR PHYSIOLOGY 228:1641-1646(2013).
