HMGA2

  • Official Full Name

    high mobility group AT-hook 2
  • Overview

    HMGA2 belongs to the family of high mobility group with AT-hook DNA binding domain. HMGA proteins are considered architectural transcription factors; they do not have direct transcriptional activation capacity, but instead regulate gene expression by chan
  • Synonyms

    HMGA2;high mobility group AT-hook 2;high mobility group (nonhistone chromosomal) protein isoform I C , HMGIC;high mobility group protein HMGI-C;BABL;LIPO;High-mobility group protein HMGI-C;high mobility group AT-hook protein 2;high-mobility group

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • GST
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
HMGA2-13840H Recombinant Human HMGA2, GST-tagged E.coli Human GST 1-108a.a.
HMGA2-11956Z Recombinant Zebrafish HMGA2 Mammalian Cells Zebrafish His
HMGA2-4865H Recombinant Human HMGA2 Protein, GST-tagged Wheat Germ Human GST
HMGA2-592H Recombinant Human high mobility group AT-hook 2, His-tagged E.coli Human His 1-109 a.a.
HMGA2-6559C Recombinant Chicken HMGA2 Mammalian Cells Chicken His
HMGA2-7727M Recombinant Mouse HMGA2 Protein Mammalian Cells Mouse His
HMGA2-5478HCL Recombinant Human HMGA2 293 Cell Lysate HEK293 Human Non
Hmga2-1139M Recombinant Mouse Hmga2 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
HMGA2-178H Recombinant Human HMGA2 protein, His/GST-tagged E.coli Human GST&His 109
Hmga2-179M Recombinant Mouse Hmga2 Protein, His/GST-tagged E.coli Mouse GST&His Met1~Asp108
HMGA2-3199H Recombinant Human HMGA2 Protein (Met1-Asp109), N-His tagged E.coli Human His Met1-Asp109
HMGA2-3200H Recombinant Human HMGA2 Protein E.coli Human Non
HMGA2-4236M Recombinant Mouse HMGA2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
HMGA2-4236M-B Recombinant Mouse HMGA2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    HMGA2 involved in several pathways and played different roles in them. We selected most pathways HMGA2 participated on our site, such as Transcriptional misregulation in cancer,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transcriptional misregulation in cancer ITGB7,SIN3A,SPI1,RUNX2,ETV7,TP53,LMO2,ELANE,FUS,IL3
    MicroRNAs in cancer CDC25A,DNMT3A,TPM1,MDM2,CCNE2,CDCA5,GLS2,PRKCA,MMP9,FGFR3

    Protein Function

    HMGA2 has several biochemical functions, for example, 5-deoxyribose-5-phosphate lyase activity,AT DNA binding,C2H2 zinc finger domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGA2 itself. We selected most functions HMGA2 had, and list some proteins which have the same functions with HMGA2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding, bending TOP2B,TOP2A,TFAM,HHEX,FOXI1,GATA1,FOXC1,SRY,HMGB2,FOXD1
    cAMP response element binding CREB3L1,JUN,CREB3L3,CREB3L2,CREB1,ATF6B,CREB3,E4F1,ATF6,CREB3L3A
    transcription factor binding TCF7L2,PIANP,HMGB1,NR0B2A,CHCHD2,PURB,YWHAZ,BCL10,PPID,HES2
    C2H2 zinc finger domain binding GATA2,GATA1,EBF1,EHMT2,WT1,ZXDC,EHMT1,TAF9,LEF1,THAP7
    AT DNA binding POU3F4,CRIP1,HMGA1,MEF2C
    SMAD binding ACVR1B,AXIN1,TGFBR1,TCF12,SOD3,BMPR1A,SMURF2,TGFBR3,YY1,PML
    DNA binding KDM5D,ARID1A,FANCM,ZSCAN18,SOX3,ZFP879,ZNF180,NFYAL,IMPDH1,MGAA
    DNA-(apurinic or apyrimidinic site) lyase activity RPS3,ALKBH1,NTHL1,HMGA1B,APEX1,APEX2,NEIL1,HMGA1-RS1,HMGA1A,HMGA1
    core promoter binding EZH2,SFPQ,SFPI1,MED1,EP300,NONO,HDAC4,RBMX,NPAS2,HDAC5

    Interacting Protein

    HMGA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGA2.

    PRMT6;PRMT1;ssdna_dadts;H2AFX;ATM

    Resources

    References

    • Rudzinski, ER; Anderson, JR; et al. Myogenin, AP2 beta, NOS-1, and HMGA2 Are Surrogate Markers of Fusion Status in Rhabdomyosarcoma A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:654-659(2014).
    • Chieffi, P; Chieffi, S; et al. Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: An overview. JOURNAL OF CELLULAR PHYSIOLOGY 228:1641-1646(2013).

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