hly
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Official Full Name
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Overview
The secreted pore-forming protein listeriolysin O (LLO) is an essential virulence determinant of the facultative intracellular bacterium Listeria monocytogenes that allows the pathogen to escape from the phagocytic vacuole and reach the host cytosol. LLO is a single polypeptide protein encoded by the hlyA gene and composed of 529 residues. At its NH2-terminus it possesses a 25 residues long typical signal sequence excited during the secretion process. Moreover, in its NH2-terminus there is also a 19 amino acids PEST- like sequence that may target this toxin for degradation. This motif seems to be essential for bacterial virulence too, since its deletion causes a defect in bacterium phagosomal escaping. -
Synonyms
Hly;listeriolysin O;identified by similarity to SP:P13128;match to protein family HMM PF01289
Recombinant Proteins
- Listeria monocytogenes
- S.alpha
- Staphylococcus Aureus
- Staphylococcus aureus
- Listeria monocytogenes serotype 1/2a (strain 08-5923)
- E.coli
- Yeast
- Non
- His&SUMO
- His
Involved Pathway
hly involved in several pathways and played different roles in them. We selected most pathways hly participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with hly were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
hly has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by hly itself. We selected most functions hly had, and list some proteins which have the same functions with hly. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
hly has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hly here. Most of them are supplied by our site. Hope this information will be useful for your research of hly.
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