HLA-DRA
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Official Full Name
major histocompatibility complex, class II, DR alpha -
Overview
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. -
Synonyms
MLRW;FLJ51114;HLA-DRA1;HLA-DRA;HLA class II histocompatibility antigen, DR alpha chain;OTTHUMP00000029406;OTTHUMP00000029407;MHC class II antigen DRA;MHC cell surface glycoprotein;histocompatibility antigen HLA-DR alpha;RLA-DR-ALPHA;major histocompatibility complex, class II, DR alpha;ENSOCUG00000009103;chromosome: 12
Recombinant Proteins
- Human
- E.coli
- HEK293
- Yeast
- His
- Non
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-DRA-490H | Recombinant Human major histocompatibility complex, class II, DR alpha, His-tagged | E.coli | Human | His | 26-216 a.a. |
|
| HLA-DRA-5501HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | Human | Non |
|
|
| HLA-DRA-2300H | Recombinant Human HLA-DRA Protein (26-254 aa), His-tagged | Yeast | Human | His | 26-254 aa |
|
| HLA-DRA-231H | Recombinant Human HLA-DRA protein, GST-tagged | E.coli | Human | GST | 24-218 aa |
|
| HLA-DRA-353H | Recombinant Human HLA-DRA Protein, His-tagged | E.coli | Human | His | Lys27~Glu216 |
|
| HLA-DRA-3571H | Recombinant Human HLA-DRA Protein (Lys27-Glu216), His tagged | E.coli | Human | His | Lys27-Glu216 |
|
| HLA-DRA-5321H | Recombinant Human HLA-DRA protein, His-tagged | E.coli | Human | His | 28-254aa |
|
Involved Pathway
HLA-DRA involved in several pathways and played different roles in them. We selected most pathways HLA-DRA participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leishmaniasis | NCF4,IRAK4,NCF2,NFKBIA,HLA-DPA1,PTGS2,STAT1,ELK1,MARCKSL1,RELA |
| Asthma | IL10,HLA-DQB1,HLA-DRB1,HLA-DRB3,IL3,H2-AA,HLA-DMA,HLA-DQA2,HLA-DQA1,HLA-DOA |
| Systemic lupus erythematosus | C3,FCGR3A,HIST1H2AM,H2-AB1,HIST1H2BL,HIST1H2BB,HIST1H2BP,HIST1H2BG,C1S,HIST3H2BB-PS |
| Autoi | TPO,H2-Q10,IFNA21,H2-AB1,IL5,HLA-DPB1,IFNA7,IFNA16,HLA-DPA1,HLA-DRB4 |
| Hematopoietic cell lineage | KITLG,ITGAM,TFRC,IL3,ITGA6,CSF3,GP5,ITGA5,IL11,CSF3R |
| Herpes simplex infection | CFP,TAB2,MED8,IFNG,STAT2,HLA-F,OAS3,PER2,FASLG,HMGN1 |
| ne network for IgA production | CXCL12B,IL6,HLA-DPB1,CD80,TNFRSF13B,TGFB1,CXCR4B,BMA2,HLA-DRB4,LTBR |
| Cell adhesion molecules (CAMs) | PTPRF,CLDN14,PTPRM,CLDN7B,NEGR1,CLDN7,SELPLG,ITGAL,MPZ,CLDN10 |
| Graft-versus-host disease | KLRD1,CD86,IL1B,HLA-DPA1,FAS,HLA-DRB4,HLA-F,IFNG,IL1A,HLA-A |
Protein Function
HLA-DRA has several biochemical functions, for example, MHC class II protein complex binding,MHC class II receptor activity,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRA itself. We selected most functions HLA-DRA had, and list some proteins which have the same functions with HLA-DRA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class II receptor activity | HLA-DQA1,HLA-DPA1,HLA-DQA2,KRT17,HLA-DOB,HLA-DRB3,HLA-DQB2,HLA-DQB1,HLA-DOA,HLA-DRB1 |
| peptide antigen binding | HLA-DRB1,HLA-A,BF2,MHC1UBA,DHCR24,HLA-DRB3,HLA-DPB1,HLA-F,MHC1UFA,HLA-DQA1 |
| MHC class II protein complex binding | HLA-DMB,PKM2,ANXA11,HSP90AA1,CD74,HSP90AB1,HLA-DOA,CD81,HSPA8,HLA-DMA |
Interacting Protein
HLA-DRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRA.
HLA-DRB1;HLA-DRB1;HLA-DMA
Resources
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References
- Gan, SJ; Ye, B; et al. Immune- and Ribosome-Related Genes were Associated with Systemic Vasculitis. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:96-101(2015).
- Tu, WL; Liu, YQ; et al. Genome-Wide Loci Linked to Non-Obstructive Azoospermia Susceptibility May Be Independent of Reduced Sperm Production in Males with Normozoospermia. BIOLOGY OF REPRODUCTION 92:-(2015).
